AI Article Synopsis
- The initial use of glucocorticoids proved highly effective in treating severe rheumatoid arthritis, offering significant symptom relief.
- Adverse effects from high doses caused them to fall out of favor for about 20 years, with many considering them inappropriate for treatment.
- Recently, growing evidence and clinical practices have led to a revival of glucocorticoids as a recommended first-line treatment option.
Article Abstract
The first therapeutic use of glucocorticoids was in a patient with severe rheumatoid arthritis and the symptomatic benefit was astounding. Adverse effects from increasingly large doses led to them being overshadowed, dismissed as inappropriate treatment, and ignored for 20 years - but in the last 2 decades, the accumulating evidence and clinical practice suggest there is a justified renaissance in their use as a first-line treatment.
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| http://dx.doi.org/10.1002/cpt.753 | DOI Listing |
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