AI Article Synopsis
- The study examined the survival rates of patients with oropharyngeal squamous cell carcinoma (SCC) based on their p16 biomarker status, finding that HPV-related cases generally have better survival outcomes.
- Patients with p16-positive tumors showed similar survival rates, whether they underwent surgical or nonsurgical treatments, whereas p16-negative patients had improved survival with surgical intervention.
- The results suggest that while p16-positive patients can choose between treatments without impacting their outcomes, p16-negative patients might benefit more from surgery followed by additional therapy.
Article Abstract
Background: The incidence of human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (SCC) is increasing and has better survival than non-HPV related oropharyngeal SCC. This study compared surgical to nonsurgical treatments and demographic, clinical, and survival differences in patients with oropharyngeal SCC, stratified by p16 status.
Methods: We assembled a cohort of adult patients with oropharyngeal SCC diagnosed between 2000 and 2008 in Alberta. The tumor p16 biomarker was measured using fluorescent immunohistochemistry.
Results: In this cohort, p16 data were available for 115 of 357 patients; and 66% (n = 76) were p16-positive. Patients with p16 data had comparable outcomes to those without. Surgically treated p16-negative patients had improved 5-year disease-specific survival (DSS) and overall survival (OS) compared with nonsurgical patients. There were no differences in survival outcomes between surgical and nonsurgical treatment for patients with p16-positive disease.
Conclusion: Patients with p16-positive oropharyngeal SCC had similar outcomes regardless of treatment. Patients with p16-negative tumors may benefit from primary surgery with postoperative adjuvant therapy.
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| http://dx.doi.org/10.1002/hed.24889 | DOI Listing |
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