Background: Application the innovative method which is in ovo technology provides a means of modulating the immune system at early embryonic stages. The aim of study was to determine influence of the in ovo stimulation, on d 12 of incubation, with synbiotics (synbiotic 1- IBB3154 + Bitos, Clasado Ltd. and the synbiotic 2 - IBB3036 + lupin RFOs) on the microstructure of duodenum, jejunum and ileum in the 1 and 42 day of rearing.
Results: On the 1 day of chickens life, in the duodenum of both experimental groups (SYN1 and SYN2), a significantly higher and wider intestinal villi as well as a significantly larger absorbent surface of these villi were found in comparison with the Control group ( ≤ 0.01). On the 42 day of rearing the beneficial effect of synbiotic 1 was reflected by the numerically higher villi (no statistical differences) with a larger surface ( ≤ 0.01) in the duodenum in the SYN1 group compare to the Control group. In the jejunum on the 1 day of life, in the SYN1 group, significantly higher villi than in the Control group, with a simultaneous decrease in the depth of crypts ( ≤ 0.01), and also the largest width of villi and their absorbent area ( ≤ 0.01) in comparison to the other groups were found. On the 42 day of life, in the jejunum, an increase in the height of the villi whilst reducing the crypt depth in the SYN2 group was found ( ≤ 0.01). In turn, in the SYN1 group, there were significantly more neutral goblet cells observed compared with the control group ( ≤ 0.05). In the ileum of 1-day-old chickens, the widest villi ( ≤ 0.05) and the deepest crypts ( ≤ 0.01) were found in the SYN2 group. In the same group, there was also the least amount of neutral goblet cells in comparison to the other groups ( ≤ 0.05).
Conclusions: We observed that synbiotic 1 and 2 beneficially affected the examined characteristics on the 1 and 42 day of life. The obtained results allow us to conclude that the use of synbiotics significantly affect gut structure which should contribute to improvement in nutrient absorption by the gut.
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http://dx.doi.org/10.1186/s40104-017-0193-1 | DOI Listing |
Neurol Res
January 2025
Department of Physiology, Faculty of Medicine, Izmir Democracy University, Izmır, Turkey.
Objective: Within the scope of this research, the long-term effects of experimental blunt head trauma on immature rats and MK-801 administered acutely after trauma on the brain tissue will be examined. In addition, the impact of trauma and MK-801 on Nestin and CD133, which are essential stem cells, will be evaluated by immunohistochemical and ELISA methods.
Methods: In this study, the contusion trauma model was used.
Pest Manag Sci
January 2025
Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Synthetic Biology, Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China.
Background: Exogenous double-stranded RNA (dsRNA) has the potential to serve as an effective alternative to conventional chemical pesticides for the control of insect pests, because it can specifically inhibit essential gene expression in these organisms. However, identifying suitable gene targets remains a crucial step in the development of RNA interference (RNAi)-based pest control strategies.
Results: In this study, three apoptosis-related genes were selected to evaluate their potential for RNAi-induced lethality in Henosepilachna vigintioctopunctata via foliar spray dsRNAs.
Knee Surg Sports Traumatol Arthrosc
January 2025
Department of Joint Surgery and Sports Medicine, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Purpose: This study aimed to investigate whether combining the analysis of different magnetic resonance imaging (MRI) signs enhances the diagnostic accuracy of lateral meniscus posterior root tears (LMPRTs) in patients with anterior cruciate ligament (ACL) injuries. We hypothesised that analysing the cleft, ghost and truncated triangle signs and lateral meniscus extrusion (LME) measurement together would improve the preoperative MRI-based diagnosis of LMPRTs.
Methods: This retrospective study used prospectively collected registry data from two academic centres, including patients undergoing primary or revision ACL reconstruction (ACLR) and LMPRT repair.
Am J Ind Med
January 2025
Icahn School of Medicine at Mount Sinai, Selikoff Centers for Occupational Health, New York, New York, USA.
Background: Housecleaning work has been characterized as precarious employment with unstable work hours, arbitrary and low pay and benefits, and exposures to chemical, physical, and psychosocial stressors. Understanding how interpersonal power dynamics between workers and clients, a component of precarious work, contributes to work exposures can inform and improve prevention programs.
Methods: We used reflexive thematic analysis of data from seven focus groups with Latinx immigrant housecleaners in New York City to explore workers' experience of interpersonal power dynamics with their clients-whom they referred to as their "employers"-and its influences on working conditions.
J Adv Nurs
January 2025
Nursing Science (INS), Department Public Health (DPH), Faculty of Medicine, University of Basel, Basel, Switzerland.
Aim: To implement and evaluate an Advanced Practice Nurse-led transitional care model (AdvantAGE) to reduce rehospitalisation rates in frail older adults discharged from a Swiss geriatric hospital.
Design: The study adopts an effectiveness-implementation hybrid design (Type 1) to simultaneously evaluate the effectiveness of the care model and explore the implementation process.
Methods: The primary outcome, the 90-day rehospitalisation rate, will be evaluated using a matched-cohort design with a prospective intervention group and a retrospective control group.
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