A straightforward enantiomerically pure synthesis of the heterocyclic core of the D-series GE2270 is reported. The synthetic strategy combines the Hantzsch thiazole's building condensation with a cross-coupling reaction including direct C-H hetarylation to build and connect step-by-step thiazolyl moieties to the 5-bromopicolinate as readily available starting material.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530635 | PMC |
| http://dx.doi.org/10.3762/bjoc.13.137 | DOI Listing |
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