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Differences in safety profiles of anti-herpesvirus medications: a real-world pharmacovigilance study based on the FAERS database.
Expert Opin Drug Saf
October 2024
Department of Pharmacy, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Article Synopsis
- The study compared the safety profiles of four anti-herpesvirus drugs—acyclovir, ganciclovir, valaciclovir, and foscarnet—using data from the FDA Adverse Event Reporting System from 2004 to 2023.
- All drugs showed significant risks for hematotoxicity, with ganciclovir and foscarnet being the most myelosuppressive.
- Specific associations were noted: foscarnet posed the highest risk for renal impairment and seizures, while acyclovir had strong ties to neurotoxicity and severe skin reactions.
EPSTEIN-BARR VIRUS ACUTE RETINAL NECROSIS IN AN IMMUNOCOMPETENT HOST.
Retin Cases Brief Rep
July 2021
Department of Ophthalmology, Jewish General Hospital, Montreal, Quebec, Canada.
Purpose: To describe a case of Epstein-Barr virus (EBV)-associated acute retinal necrosis (ARN) in an immunocompetent patient and to summarize the clinical features of published molecularly confirmed EBV-ARN cases.
Methods: Case report and literature review.
Results: An 83-year-old immunocompetent woman with unilateral ARN presented with visual acuity of light perception.
A unique presentation of acute liver failure from herpes simplex virus hepatitis.
Transpl Infect Dis
August 2016
Department of Pathology, Division of Pathology and Laboratory Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.
We present the case of a patient, with history of myelodysplastic syndrome and recent bone marrow transplant, who developed fulminant liver failure secondary to herpes simplex virus (HSV) hepatitis. His presentation was unique, as findings of liver microabscesses on computed tomography scan have not been described previously in this patient population. Despite initial treatment with acyclovir, he continued to deteriorate, and later sensitivities found the HSV strain to be resistant to acyclovir.
View Article and Find Full Text PDFBilateral central retinal artery occlusion associated with herpes simplex virus-associated acute retinal necrosis and meningitis: case report and literature review.
Ophthalmic Surg Lasers Imaging Retina
February 2015
A 60-year-old woman with a history of recurrent headaches and blurred vision presented with bilateral optic disc edema. Optic neuritis was suspected, and intravenous methylprednisonlone was administered. Her vision declined to hand motions in both eyes, and subsequent evaluation revealed bilateral acute retinal necrosis with bilateral central retinal artery occlusions (CRAO).
View Article and Find Full Text PDF[Herpes simplex virus type 2 fulminant hepatitis after umbilical cord blood transplantation for acute myeloid leukemia].
Rinsho Ketsueki
June 2014
Department of Hematology, Toranomon Hopital.
This report describes a 41-year-old patient, who developed herpes simplex virus type 2 (HSV-2)-hepatitis after umbilical cord blood transplantation (CBT). The patient had received allogeneic bone marrow transplantation from an unrelated donor for acute myeloid leukemia (AML) not in remission. AML relapsed 18 months after the first transplantation, and CBT was performed.
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