Using gold nanoparticle-templated high-density lipoprotein-like particles as a model, the nanoparticle-templated phospholipid bilayer is studied from the bottom-up. Data support the phospholipids have a mosaic interdigitated structure. The discontinuous lipid milieu supports partial lipidation of apolipoprotein A-I, different from an ordinary phospholipid bilayer, suggesting that synergy between nanoparticle templates and bound phospholipid layers can modulate amphiphilic proteins for desired functions.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544021 | PMC |
| http://dx.doi.org/10.1002/ppsc.201600032 | DOI Listing |
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