AI Article Synopsis
- There is a growing demand for bio-compatible polymers with a diverse range of properties, specifically focusing on poly(glycerol-adipate) (PGA), which is made from enzymatic reactions involving divinyl adipate and glycerol.
- PGA can be synthesized into various forms, including acylated versions with different fatty acid chain lengths that change its properties, enabling the creation of comb-like structures.
- The study showcases techniques like FT-IR, H NMR, and DLS to analyze and confirm PGA’s tunable attributes, making it a promising biodegradable polymer for applications in healthcare like drug delivery systems.
Article Abstract
There is an increasing need to develop bio-compatible polymers with an increased range of different physicochemical properties. Poly(glycerol-adipate) (PGA) is a biocompatible, biodegradable amphiphilic polyester routinely produced from divinyl adipate and unprotected glycerol by an enzymatic route, bearing a hydroxyl group that can be further functionalized. Polymers with an average Mn of ∼13 kDa can be synthesized without any post-polymerization deprotection reactions. Acylated polymers with fatty acid chain length of C, C, and C (PGAB, PGAO, and PGAS, respectively) at different degrees of substitution were prepared. These modifications yield comb-like polymers that modulate the amphiphilic characteristics of PGA. This novel class of biocompatible polymers has been characterized through various techniques such as FT-IR, H NMR, surface, thermal analysis, and their ability to self-assemble into colloidal structures was evaluated by using DLS. The highly tunable properties of PGA reported herein demonstrate a biodegradable polymer platform, ideal for engineering solid dispersions, nanoemulsions, or nanoparticles for healthcare applications. © 2016 The Authors. Journal of Polymer Science Part A: Polymer Chemistry Published by Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. , , 3267-3278.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516180 | PMC |
| http://dx.doi.org/10.1002/pola.28215 | DOI Listing |
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