AI Article Synopsis
- Qiao et al. (2017) investigate the preferred nucleic acid substrates for the enzyme AID, which is crucial for DNA mutations during processes like class switch recombination (CSR) and somatic hypermutation (SHM).
- They utilize biochemical and structural techniques to understand how AID identifies and interacts with these substrates.
- Their findings enhance the understanding of AID's targeting mechanisms, shedding light on its role in immune responses.
Article Abstract
In this issue of Molecular Cell, Qiao et al. (2017) use both biochemical and structural approaches to report AID-preferred nucleic acid substrates, illuminating AID targeting mechanisms during CSR and SHM.
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| http://dx.doi.org/10.1016/j.molcel.2017.07.020 | DOI Listing |
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