Combining hiPSCs and Human Genetics: Major Applications in Drug Development.

Cell Stem Cell

Translational Systems Biology Group, Department of Comparative Biology and Safety Sciences, Amgen Inc., Cambridge, MA 02141, USA. Electronic address:

Published: August 2017

AI Article Synopsis

  • Merging iPSC models with human genetic research enhances our understanding of disease mechanisms and helps in identifying drug targets.
  • Recent applications of this approach show promising advancements in drug development across various fields.
  • However, there are still challenges to address, and potential solutions are being explored to further improve this research integration.

Article Abstract

Merging iPSC models and human genetic research has opened up new avenues in understanding disease mechanisms and target biology, which facilitate exciting translation of this research to many areas of drug development. We highlight recent applications of these combined disciplines and discuss remaining challenges and potential solutions.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stem.2017.07.012DOI Listing

Publication Analysis

Top Keywords

drug development
8
combining hipscs
4
hipscs human
4
human genetics
4
genetics major
4
major applications
4
applications drug
4
development merging
4
merging ipsc
4
ipsc models
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!