Purpose: In this tutorial we review current practice in the analysis of data obtained in designs involving two dependent samples and evaluate two conventional statistics: the t test for paired samples and its non-parametric alternative, the Wilcoxon Signed Ranks test (WSR). It is a sequel to our tutorial on the analysis of designs with two independent samples on the basis of non-count data (Rietveld & van Hout, 2015). The frequency with which these statistics are used is assessed on the basis of publications on disordered communication in Clinical Linguistics & Phonetics, Journal of Communication Disorders and Journal of Speech, Language and Hearing Research for the time interval 2006-2015. We conclude with a number of recommendations for the analysis and presentation of data.
Conclusions: Researchers should more consistently present the relevant characteristics of their data (means, medians, SD, skewness, tailedness, outliers etc.) and explicitly consider the assumptions that apply to their statistical methods, such as correlations between data obtained on two occasions, interactions between participants and treatment, and the symmetry of difference scores, many of which are hardly ever reported or even tested. Two recommendations are particularly relevant. First, the WSR is not a proper test for central tendencies as a replacement of the conventional t test for paired samples whenever assumptions about the dependent variable are in doubt. Second, researchers should choose statistical procedures on the basis of the null hypothesis (H0) to be tested and not primarily on the basis of the type of data (ordinal or interval). Two relevant H0's in the field of speech-language pathology are: (1) μ=μ (the mean obtained in condition 1 is equal to the mean in condition 2) and (2) p=0.5, which says: the probability to obtain (for instance) higher scores in condition 2 than in condition 1 is 0.5. We recommend the permuted t test for paired samples to test the first H0 and the permuted Brunner-Munzel rank test to test the second.
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http://dx.doi.org/10.1016/j.jcomdis.2017.07.002 | DOI Listing |
Arch Dermatol Res
January 2025
Division of Gastroenterology and Hepatology, 200 1st Street SW, Rochester, MN, 55905, USA.
Background: Celiac disease (CeD) has shown an association with autoimmune disorders including vitiligo and alopecia areata (AA). Ritlecitinib, a JAK3 and TEC kinase family inhibitor, has been approved for treatment of patients with AA and is in late-stage development for vitiligo. Ritlecitinib inhibits cytotoxic T cells, NK cells, and B cells which play a role in the pathogenesis of CeD.
View Article and Find Full Text PDFAnal Methods
November 2017
Anhui Key Laboratory of Chemo-Biosensing, Key Laboratory of Functional Molecular Solids, Ministry of Education, College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241000, PR China.
A new aptamer-based surface plasmon resonance (SPR) system has been designed to detect Hg that utilizes near-infrared (NIR)-to-NIR gold nanoparticle coated NaYF:Yb,Tm,Gd up-conversion nanoparticles (AuNPs@NaYF:Yb,Tm,Gd UCNPs) as probes. The AuNPs@NaYF:Yb,Tm,Gd UCNPs were prepared and excited by near-infrared light (980 nm) which emitted at a near-infrared wavelength (808 nm) using an inexpensive infrared continuous wave laser diode. The AuNPs@NaYF:Yb,Tm,Gd UCNPs were conjugated with Hg aptamers.
View Article and Find Full Text PDFBMC Psychol
January 2025
Management Department, College of Business, King Saud University, Riyadh, Saudi Arabia.
Purpose: The present study aimed to analyze the effectiveness of external and personal regulatory mechanisms in reducing procrastination behavior among university students. For this purpose, the role of teachers' academic motivation is worthwhile in shaping the learning environment and reducing procrastination, with a focus on the mediating roles of emotion regulation and study habits considered imperative.
Research Design/method: By employing a quantitative, cross-sectional research design, data were collected from a sample of 210 teachers working in universities located in Multan-Pakistan via convenient sampling, yielding a usable response rate of 70.
Cancer Cell Int
January 2025
Department of Laboratory Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Korea.
Background: The prognosis of a plasma cell neoplasm (PCN) varies depending on the presence of genetic abnormalities. However, detecting sensitive genetic mutations poses challenges due to the heterogeneous nature of the cell population in bone marrow aspiration. The established gold standard for cell sorting is fluorescence-activated cell sorting (FACS), which is associated with lengthy processing times, substantial cell quantities, and expensive equipment.
View Article and Find Full Text PDFJ Gen Intern Med
January 2025
General Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.
Purpose: Physicians are estimated to be responsible for more than 50% of national healthcare costs and hold the greatest potential to improve value by orchestrating quality-driven programs to reduce unnecessary practices and variability. A physician's ability to practice cost-conscious care has been linked to their training, underscoring the importance of integrating cost-conscious practice into training.
Methods: The High Value Practice Academic Alliance was formed to help advance the value-improvement work of individual institutions through a national organization.
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