AI Article Synopsis
- The study aimed to assess the impact of decreased fibrinolytic activity and the PAI-1 4G/5G polymorphism on the risk of developing venous thrombosis.
- Researchers conducted a case-control study with 100 venous thrombosis patients and 100 controls, finding that lower fibrinolytic activity increased the risk of thrombosis by 2.7 times.
- The PAI-1 4G/5G gene variant did not significantly influence the risk of venous thrombosis compared to the 5G/5G genotype, indicating that decreased fibrinolytic activity is a more critical factor in this context.*
Article Abstract
: Objective of our study is to determine whether decreased fibrinolytic activity or plasminogen activator inhibitor (PAI)-1 4G/5G polymorphism influence the risk of venous thrombosis.Our case-control study included 100 patients with venous thrombosis, and 100 random controls. When patients were compared with random controls, unconditional logistic regression was used to calculate odds ratios (ORs) with 95% confidence intervals (CIs).Decreased fibrinolytic activity yielded a 2.7-fold increase in risk for venous thrombosis than physiological fibrinolytic activity (OR 2.70; 95% CI 1.22-5.98), when comparing patients with random controls. Adjustment for several putative confounders did not change the estimate (OR 3.02; 95% CI 1.26-7.22). Analysis of venous thrombotic risk influenced by PAI-1 genotype, showed no influence of PAI-1 4G/5G gene variant in comparison with 5G/5G genotype (OR 0.57 95% CI; 0.27-1.20).Decreased fibrinolytic activity increased, whereas PAI-1 4G/5G polymorphism did not influence venous thrombosis risk in this study.
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| http://dx.doi.org/10.1097/MBC.0000000000000656 | DOI Listing |
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