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Presentation and diagnosis of childhood-onset combined pituitary hormone deficiency: A single center experience from over 30 years.
EClinicalMedicine
September 2022
Helsinki University Hospital, New Children's Hospital, Pediatric Research Center, Helsinki 00014, Finland.
Background: Childhood-onset combined pituitary hormone deficiency (CPHD) has a wide spectrum of etiologies and genetic causes for congenital disease. We aimed to describe the clinical spectrum and genetic etiologies of CPHD in a single tertiary center and estimate the population-level incidence of congenital CPHD.
Methods: The retrospective clinical cohort comprised 124 CPHD patients (48 with congenital CPHD) treated at the Helsinki University Hospital (HUH) Children's Hospital between 1985 and 2018.
Creative and Innovative Methods and Techniques for the Challenges in the Management of Adult Craniopharyngioma.
World Neurosurg
October 2020
Department of Neurosurgery, Toronto Western Hospital, Toronto, Ontario, Canada. Electronic address:
Craniopharyngioma remains a major challenge in daily clinical practice. The pathobiology of the tumor is still elusive, and there are no consensus or treatment guidelines on the optimal management strategy for this relatively rare tumor. However, recent technical and scientific advances, including genomic and radiomic profiling, innovation in surgical approaches, more precise radiotherapy protocols, targeted therapy, and restoration of lost functions all have the potential to significantly improve the outcome of patients with craniopharyngioma in the near future.
View Article and Find Full Text PDFGrowth and weight of children with craniopharyngiomas based on the tumour location and growth pattern.
J Clin Neurosci
December 2013
Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou Street North 1838, Guangzhou 510515, Guangdong, China. Electronic address:
This study aimed to characterise the weight and growth of children with craniopharyngiomas and to analyse the role of the tumour location and growth pattern in the development of obesity and growth retardation in these children. We retrospectively analysed the records of 109 consecutive children with primary craniopharyngiomas. The patients were divided into two subgroups according to the location of the tumour: intrasellar (Group A); and the floor of the third ventricle (Group B).
View Article and Find Full Text PDFA 7-month-old infant with Cushing's disease.
J Coll Physicians Surg Pak
August 2013
Department of Paediatrics, The Children's Hospital, Lahore, Pakistan.
Cushing's disease in children is not rare but in infants it is quite rare and an important medical condition needing proper line of investigations and management options. Craniopharyngioma as a cause of Cushing's disease is well reported and practical inference of the condition is of clinical importance. Craniopharyngioma generally affects children at 5 - 10 years of age and is rarely seen in infancy.
View Article and Find Full Text PDFInfant brain tumors: a neuropathologic population-based institutional reappraisal.
Hum Pathol
October 2012
Division of Anatomic Pathology, Department of Pathology and Laboratory Medicine, Vancouver, British Columbia.
The factors that impact the long-term functional outcome for infants with brain tumor are unclear. The clinicopathologic features of all infant brain tumors occurring at our institution (1982-2005) were reexamined to explore the factors influencing prognosis. The details of the neuropathologic review are reported herein.
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