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http://dx.doi.org/10.3324/haematol.2017.171694 | DOI Listing |
J Lab Physicians
December 2022
Department of Biochemistry, Maulana Azad Medical College, New Delhi, India.
Serum protein electrophoresis (SPEP) is a method by which proteins present in serum are separated into different fractions based on their molecular weight and electric charge. Presence of M spike, composed of monoclonal protein, on electrophoretogram is a characteristic finding that can be seen in monoclonal gammopathies like multiple myeloma. M spike is most commonly seen in the gamma region however, the M-spike can be observed in fraction other than the Y fraction as well i.
View Article and Find Full Text PDFJ Int Med Res
February 2020
Department of Hematology, Tianjin Medical University General Hospital, Tianjin, China.
Hyperglobulinemia is a common manifestation of plasma cell disease, and it is sometimes caused by autoimmune diseases (AIDs). We report an uncommon presentation of hyperglobulinemia, with a high amount of plasma cells in bone marrow, pancytopenia, hematemesis, and splenomegaly in an 18-year-old woman. Some examinations were performed to determine the diagnosis, including serum protein electrophoresis, immunofixation electrophoresis, the free light chain assay, abdominal enhanced computed tomography (CT) and CT venography, and positron-emission tomography-CT.
View Article and Find Full Text PDFHaematologica
November 2017
Division of Clinical Biochemistry, Mayo Clinic, Rochester, MN, USA
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