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CRISPR-Cas13d: RNA's own Jedi Master in the fight against viral darkness.
Mol Ther Nucleic Acids
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Genome Engineering and Model Development Laboratory, IUF-Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany.
Positive selection in cilia-related genes may facilitate deep-sea adaptation of Thermocollonia jamsteci.
Sci Total Environ
November 2024
CAS Key Laboratory of Marine Ecology and Environmental Sciences, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China; Laoshan Laboratory, Qingdao 266237, China; Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao 266071, China; College of Basic Medical Sciences, China Three Gorges University, Yichang 443000, China. Electronic address:
Deep-sea hydrothermal vents are characterized by high hydrostatic pressure, hypoxia, darkness and toxic substances. However, how organisms adapt to such extreme marine ecosystems remain poorly understood. We hypothesize that adaptive evolution plays an essential role in generating novelty for evolutionary adaptation to the deep-sea environment because adaptive evolution has been found to be critical for species origin and evolution.
View Article and Find Full Text PDFPhototrophic Fe(II) oxidation benefits from light/dark cycles.
Environ Microbiol Rep
April 2024
School of Earth Sciences, University of Bristol, Bristol, UK.
Phototrophic Fe(II)-oxidizers use Fe(II) as electron donor for CO fixation thus linking Fe(II) oxidation, ATP formation, and growth directly to the availability of sunlight. We compared the effect of short (10 h light/14 h dark) and long (2-3 days light/2-3 days dark) light/dark cycles to constant light conditions for the phototrophic Fe(II)-oxidizer Chlorobium ferrooxidans KoFox. Fe(II) oxidation was completed first in the setup with constant light (9 mM Fe(II) oxidised within 8.
View Article and Find Full Text PDFDiurnal metabolic control in cyanobacteria requires perception of second messenger signaling molecule c-di-AMP by the carbon control protein SbtB.
Sci Adv
December 2021
Organismic Interactions Department, Interfaculty Institute for Microbiology and Infection Medicine, Cluster of Excellence 'Controlling Microbes to Fight Infections', Tübingen University, Auf der Morgenstelle 28, 72076 Tübingen, Germany.
Because of their photosynthesis-dependent lifestyle, cyanobacteria evolved sophisticated regulatory mechanisms to adapt to oscillating day-night metabolic changes. How they coordinate the metabolic switch between autotrophic and glycogen-catabolic metabolism in light and darkness is poorly understood. Recently, c-di-AMP has been implicated in diurnal regulation, but its mode of action remains elusive.
View Article and Find Full Text PDFAmphiphilic Fullerene-BODIPY Photosensitizers for Targeted Photodynamic Therapy.
ChemMedChem
March 2022
Department of Chemistry, Faculty of Science, Gebze Technical University, Gebze, Kocaeli, 41400, Turkey.
Nanotheranostic tailor-made carriers are potent platforms for the treatment of cancer that propound a number of advantages over conventional agents for photodynamic therapy (PDT). Herein, four new heavy atom free amphiphilic glucose-BODIPY-fullerene dyads (14-17) endowed with carbohydrate units in the styryl units, which can also form nanomicelles (14-17NM) with Tween 80 for PDT are reported. Glucose-BODIPY-fullerene systems (14-17) and related nanomicelles (14-17NM) have been prepared to emcee efficient singlet oxygen generation upon light irradiation.
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