The fracture behaviors of quasi-brittle materials are commonly specimen size (size effect) and crack size (boundary effect) dependent. In this study, a new failure model is developed for characterizing the size and boundary effects. The derivative of the energy release rate is firstly introduced to predict the nominal strength dominated by the strength mechanism. Combined with the energy criterion for the energy mechanism, an asymptotic model is developed to capture the effect of any crack size on the nominal strength, and its expression for geometrically similar specimens is also established, which is able to characterize the size effect. Detailed comparisons of the proposed model with the size effect law and the boundary effect model are performed, respectively. The nominal strength predictions based on the proposed model are validated with the experimental results of cracked three-point bending beam specimens made of concrete, of limestone and of hardened cement paste and compared with the model predictions given by the size effect law and the boundary effect model.
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http://dx.doi.org/10.3390/ma9121030 | DOI Listing |
Sci Rep
January 2025
Department of Physics, University of Oslo, P.O. Box 1048 Blindern, 0316, Oslo, Norway.
In the subauroral zone at the boundary of the auroral oval in the evening and night hours during geomagnetic disturbances, a narrow (about 1°-2°) and extended structure (several hours in longitude) is formed. It is known as a polarization jet (PJ) or the subauroral ion drift (SAID). The PJ/SAID is a fast westward ion drift and is one of the main signatures of a geomagnetic disturbance in the subauroral ionosphere at the altitudes of the F-layer, when the geomagnetic AE index reaches more than 500 nT.
View Article and Find Full Text PDFGenes Dev
January 2025
Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), University Medical Center Utrecht, Utrecht 3584 CT, the Netherlands;
Enhancers are tissue-specific regulatory DNA elements that can activate transcription of genes over distance. Their target genes most often are located in the same contact domain-chromosomal entities formed by cohesin DNA loop extrusion and typically flanked by CTCF-bound boundaries. Enhancers shared by multiple unrelated genes are underexplored but may be more common than anticipated.
View Article and Find Full Text PDFMater Today Bio
February 2025
Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China.
Hepatocellular carcinoma (HCC) is typically diagnosed at intermediate to advanced stage, making surgical treatment unfeasible. Conversion therapy aims to reduce tumor stage, improve hepatic resection feasibility, and lower recurrence rates. Since traditional therapies are often accompanied by uncertainty of efficacy, there is an urgent need to explore new treatment strategies.
View Article and Find Full Text PDFHeliyon
January 2025
Institute for Nanomaterials, Advanced Technologies and Innovation, Technical University of Liberec, 46117, Liberec, Czech Republic.
Droplet coalescence in microchannels is a complex phenomenon influenced by various parameters such as droplet size, velocity, liquid surface tension, and droplet-droplet spacing. In this study, we thoroughly investigate the impact of these control parameters on droplet coalescence dynamics within a sudden expansion microchannel using two distinct numerical methods. Initially, we employ the boundary element method to solve the Brinkman integral equation, providing detailed insights into the underlying physics of droplet coalescence.
View Article and Find Full Text PDFSensors (Basel)
January 2025
School of Internet of Things Engineering, Wuxi University, Wuxi 214105, China.
The task of nucleus segmentation plays an important role in medical image analysis. However, due to the challenge of detecting small targets and complex boundaries in datasets, traditional methods often fail to achieve satisfactory results. Therefore, a novel nucleus segmentation method based on the U-Net architecture is proposed to overcome this issue.
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