The study aimed to examine the developmental trajectories of non-symbolic and symbolic addition capacities in children and the mapping ability between these two. We assessed 106 4- to 7-year-old children and found that 4-year-olds were able to do non-symbolic addition but not symbolic addition. Five-year-olds and older were able to do symbolic addition and their performance in symbolic addition exceeded non-symbolic addition in grade 1 (approximate age 7). These results suggested non-symbolic addition ability emerges earlier and is less affected by formal mathematical education than symbolic addition. Meanwhile, we tested children's bi-directional mapping ability using a novel task and found that children were able to map between symbolic and non-symbolic representations of number at age 5. Their ability in mapping non-symbolic to symbolic number became more proficient in grade 1 (approximate age 7). This suggests children at age 7 have developed a relatively mature symbolic representation system.
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http://dx.doi.org/10.3389/fpsyg.2017.01203 | DOI Listing |
Alzheimers Dement
December 2024
Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
Background: The high prevalence of mixed‐pathology dementias suggests that multi‐drug treatments may improve clinical outcomes; thus, in‐vivo biomarkers for co‐pathologies are needed. We investigated a novel assay for detecting seeds of misfolded alpha synuclein (αSyn) and explored its relationship to outcomes including Alzheimer’s disease (AD) biomarkers, clinical features, and cognitive trajectories, in two community‐based cohorts enriched for AD risk.
Method: Cerebrospinal fluid (CSF) obtained from participants in the Wisconsin Registry for Alzheimer’s Prevention and the Wisconsin Alzheimer’s Disease Research Center (N=418 participants; 515 LPs; Table 1) was assayed using a clinically validated, qualitative Syn seed amplification assay (SAA; Amprion).
Alzheimers Dement
December 2024
Penn Alzheimer’s Disease Research Center, University of Pennsylvania, Philadelphia, PA, USA
Background: Mobile, valid and engaging cognitive assessments are essential for detecting and tracking change in research participants and patients at risk for Alzheimer’s Disease and Related Dementias (ADRDs). This pilot study aims to determine the feasibility and generalizability of an at‐home, app‐based cognitive assessment, the mobile cognitive app performance platform (mCAPP), to detect cognitive changes associated with aging and preclinical AD.
Method: mCAPP includes three gamified tasks (Figure 1): (1) a “concentration” memory task that includes learning and matching hidden card pairs with increasing memory load, pattern separation features (lure vs.
Alzheimers Dement
December 2024
Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA
Background: Highly specific ATN plasma biomarker assays for neurodegenerative diseases have been developed, but their associations with cognition vary in different populations. Kidney disease, common in diabetes, may decrease the predictive precision of those biomarkers. The aim of this study was to characterize for the first time the relationships between plasma ATN biomarkers and cognitive function in adults with T1D.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Columbia University Irving Medical Center, New York, NY, USA
Background: Cancer diagnosis is related to poor short‐term cognition, reflecting the condition, stress, and management. Less is known about long‐term relationships between time since cancer diagnosis and cognition. We evaluated the association between recency of cancer diagnosis and cognition.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of Pittsburgh, Pittsburgh, PA, USA
Background: N‐terminal brain natriuretic peptide (NTproBNP) is a marker of cardiac health and a strong predictor of mortality, incident cardiovascular disease (CVD), and sudden cardiac death in community populations. A link between the menopause transition (MT), sex hormones, and NTproBNP has been suggested, though, no studies have formally examined how NTproBNP changes over the MT. In addition of being a marker of cardiac health, studies suggest NTproBNP to be related to cognitive performance, yet those studies have not considered the MT.
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