Over a follow-up period of 6 years, 4 out of 31 live related renal allograft recipients (12.9%) developed azathioprine induced bone marrow suppression. Presentation in 3 patients was with fever and 2 patients also had associated graft dysfunction. All patients had leucopenia, 2 patients in addition had anaemia and one patient had pancytopenia. Bone marrow suppression developed 9.6 months (3.5-16.0 months) following transplantation and recovery followed over a period of 30 (18-49 days) days after withdrawal of the drug. One patient succumbed during the phase of bicytopenia.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530283 | PMC |
| http://dx.doi.org/10.1016/S0377-1237(17)30834-1 | DOI Listing |
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