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Shape-Directed Dynamic Assembly of Active Colloidal Metamachines.
ACS Nano
January 2025
School of Medicine and Health, Harbin Institute of Technology, Harbin 150080, China.
Modularly organizing active micromachines into high-grade metamachines makes a great leap for operating the microscopic world in a biomimetic way. However, modulating the nonreciprocal interactions among different colloidal motors through chemical reactions to achieve the controllable construction of active colloidal metamachines with specific dynamic properties remains challenging. Here, we report the phototactic active colloidal metamachines constructed by shape-directed dynamic self-assembly of chemically driven peanut-shaped TiO colloidal motors and Janus spherical Pt/SiO colloidal motors.
View Article and Find Full Text PDFIs gastrointestinal epithelial barrier dysfunction the only responsible for sensitization to food allergens?
Eur Ann Allergy Clin Immunol
November 2024
Clinical and Laboratory Molecular Allergy Unit, Fondazione Luigi Maria Monti, IDI-IRCCS, Rome, Italy.
Article Synopsis
- Epithelial barriers are vital for protecting against pathogens and allergens, and when environmental factors compromise them, conditions like asthma and food allergies can arise.
- While the dysfunction of skin and respiratory barriers in allergies is well-established, the gut epithelium's role in food allergies is less clear, as it usually maintains integrity and fosters immune tolerance through specific immune mechanisms.
- Research indicates that certain food allergies, such as those to cow's milk and hen's egg, often resolve with age, and studies like the LEAP trial suggest that early allergen exposure can help prevent allergies, showcasing the complex nature of allergen sensitization beyond just food intake.
Peanut-specific IgG subclasses as biomarkers of peanut allergy in LEAP study participants.
World Allergy Organ J
August 2024
Johns Hopkins University Department of Medicine, Johns Hopkins Asthma and Allergy Center, Baltimore, MD, USA.
Antigen-specific IgG2 and IgG3 are rarely measured in food allergy clinical trials despite known function in preventing mast cell and basophil activation. Our objective was to determine whether measuring peanut-specific IgG2 and IgG3 levels would correlate with peanut allergy status. Peanut-specific IgG subclasses were measured via ELISA assays in Learning Early About Peanut allergy (LEAP) trial participants at 5 years of age and were correlated with peanut allergy vs peanut sensitization vs non-peanut allergic and peanut consumption vs peanut avoidance.
View Article and Find Full Text PDFInsights into the clinical, immunologic, and genetic underpinnings of food allergy.
Immunol Rev
September 2024
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
The last few decades have seen striking changes in the field of food allergy. The prevalence of the disease has risen dramatically in many parts of the globe, and management of the condition has undergone major revision. While delayed introduction of common allergenic foods during infancy was advised for many years, the learning early about peanut allergy (LEAP) trial and other studies led to a major shift in infant feeding practices, with deliberate early introduction of these foods now recommended.
View Article and Find Full Text PDFPearls and pitfalls of implementing LEAP strategy for peanut: A case report.
J Food Allergy
April 2022
From the Department of Pediatrics, National Jewish Health, Denver, Colorado.
Early introduction of peanut in infants at high risk has been widely adopted and implemented in pediatric outpatient clinics since 2017. It is often overlooked that almost 2% of infants went on to develop peanut allergy despite regular consumption in a previous study. Here we described a case of anaphylaxis to peanut in a 6-month-old infant after a negative skin-prick test result, supervised introduction in the clinic, and successful home consumption, which, to our knowledge, has only previously been described once in the literature.
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