The Relationship Between Body Composition and Bone Quality Measured with HR-pQCT in Peritoneal Dialysis Patients.

Background: Bone is known to be impaired in chronic kidney disease and dialysis patients. Recent studies have shown that body composition (fat mass and lean mass) may impact bone health. Some of these effects may be related to mediators that are secreted by adipose tissue.

Methods: The aim of this study was to evaluate the association between body composition (dual x-ray absorptiometry [DEXA]) and adipokines (leptin, adiponectin), with bone density and microarchitecture assessed with high-resolution peripheral quantitative computed tomography (HR-pQCT) in chronic peritoneal dialysis (PD) patients in a single-center prospective study.

Results: Twenty-three patients with a median age of 61 years and body mass index (BMI) of 27 kg/m were recruited. On univariate analysis, age was negatively associated with total volumetric bone mineral density (vBMD) ( = -0.75, < 0.01), cortical vBMD ( = -0.85, < 0.01), and cortical thickness ( = -0.71, < 0.01). There was a negative association between leptin and cortical thickness ( = -0.48, = 0.021). Fat mass (FM) was negatively correlated with cortical thickness ( = -0.52, = 0.012). No association was found between bone parameters and dialysis duration, serum insulin, intact parathyroid hormone, osteocalcin, and adiponectin. The short dialysis vintage could in part explain the lack of correlation with bone parameters. In multivariate analysis, FM was significantly and negatively correlated with total vBMD, cortical and trabecular thickness.

Conclusions: These data suggest that FM is negatively associated with bone quality in PD patients, supporting a relation between body composition and bone that is independent from other dialysis-associated complications. The relative contribution of the different fat deposits (visceral versus subcutaneous) needs to be assessed in future studies.