Dental pulp is a highly specialized tissue that preserves teeth. It is important to maintain the capabilities of dental pulp before a pulpectomy by creating a local restoration of the dentin-pulp complex from residual dental pulp. The articles identified were selected by two reviewers based on entry and exit criteria. All relevant articles indexed in PubMed, Springer, Science Direct, and Scopus with no limitations from 1961 to 2016 were searched. Factors investigated in the selected articles included the following key words: Dentin-Pulp Complex, Regeneration, Tissue Engineering, Scaffold, Stem Cell, and Growth Factors. Of the 233 abstracts retrieved, the papers which were selected had evaluated the clinical aspects of the application of dentin-pulp regeneration. Generally, this study has introduced a new approach to provoke the regeneration of the dentin-pulp complex after a pulpectomy, so that exogenous growth factors and the scaffold are able to induce cells and blood vessels from the residual dental pulp in the tooth root canal. This study further presents a new strategy for local regeneration therapy of the dentin-pulp complex. This review summarizes the current knowledge of the potential beneficial effects derived from the interaction of dental materials with the dentin-pulp complex as well as potential future developments in this exciting field.
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Article Synopsis
- The study focuses on enhancing vital pulp therapy by using human umbilical cord mesenchymal stem cell-derived small extracellular vesicles (hUCMSC-sEVs) with lipopolysaccharide (LPS) pretreatment, which promotes inflammation control and stimulates dental pulp stem cells (hDPSCs) for dentin-pulp complex regeneration.
- A composite scaffold made of collagen sponge and self-assembling peptide nanofibers (CS/SAPNS) loaded with LPS-hUCMSC-sEVs was developed to facilitate the release of these vesicles to support hDPSC differentiation into osteogenic and angiogenic cells.
- The results showed that this composite scaffold effectively controlled the
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