AI Article Synopsis
- The study investigates the antidepressant-like effects of an ethyl acetate fraction derived from Tabernaemontana catharinensis leaves in mice, showing reduced immobility in certain behavioral tests.
- The effectiveness of the fraction was influenced by various pretreatments with drugs like PCPA and yohimbine, indicating potential mechanisms involved in its action.
- Chromatographic analysis revealed the presence of p-coumaric acid, suggesting it may play a critical role in the observed antidepressant effects of the fraction.
Article Abstract
This study evaluates the antidepressant-like effect and analysed the qualitative and quantitative 74 phenolic standards of ethyl acetate fraction from Tabernaemontana catharinensis leaves. Acute administration of fraction in mice reduced the immobility time in forced swimming and tail suspension tests confirming its antidepressant-like activity. The anti-immobility effect elicited by this fraction was prevented by the pretreatment of mice with PCPA (100 mg kg), ketanserin (5 mg kg), SCH 23,390 (0.05 mg kg) or yohimbine (1 mg kg). A sub effective dose of the fraction produced a synergistic effect with fluoxetine (5 mg kg). Chromatographic analysis identified 4-hydroxybenzoic and p-coumaric acids in the ethyl acetate fraction from T. catharinensis. Capillary electrophoresis presented 7.34 ± 0.02 mg g of p-coumaric acid concentration in the fraction. Therefore, it is possible that antidepressant-like effect elicited by ethyl acetate fraction from T. catharinensis be dependent on the p-coumaric acid.
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| http://dx.doi.org/10.1080/14786419.2017.1359167 | DOI Listing |
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