AI Article Synopsis
- Ochratoxin A (OTA) is a harmful compound produced by certain fungi, primarily affecting organs like the kidneys and gut.
- The study examined the effects of a 30-day exposure to low doses of OTA in young pigs, looking at their immune responses and oxidative stress levels.
- Findings revealed that even low levels of OTA significantly impacted immune functionality and antioxidant defenses, with more pronounced effects observed in the intestine compared to the kidneys.
Article Abstract
Ochratoxin A (OTA) is a secondary metabolite produced by fungi of Aspergillus and Penicillium genra. OTA is mainly nephrotoxic but can also cause hepatotoxicity, mutagenicity, teratogenicity, neurotoxicity and immunotoxicity. As recent studies have highlighted the close relationship between gastrointestinal tract and kidney, as principal organs involved in absorption and respective excretion of xenobiotics, the aim of the present study was to analyze the effect of a subchronic exposure (30 days) to 0.05 mg/kg OTA on immune response and oxidative stress parameters at the level of intestine and kidney of young swine. The experiment was realised on twelve crossbred weaned piglets randomly allotted to both control group or toxin group fed 0.050 mg OTA/kg feed. Our results have shown that a subchronic intoxication with a low dose of OTA for 30 days affected the immune response and the anti-oxidant self-defense at gut and kidney level. The gene expression of both markers of signaling pathways involved in inflammation and inflammatory cytokines were affected in a much higher extent in the gut than in the kidney Of OTA intoxicated piglets.
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| http://dx.doi.org/10.1016/j.yrtph.2017.07.031 | DOI Listing |
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