A sensitive fluorescent detection platform for Hg was constructed based on mercaptosuccinic acid (MSA) coated near-infrared (NIR)-emitting gold nanoparticles (AuNPs). The thiolated mercaptosuccinic acid was employed as both reducing agent and surface coating ligand in a one-step synthesis of NIR-emitting AuNPs (MSA-AuNPs), which exhibited stable fluorescence with the maximum wavelength at 800nm and a wide range of excitation (220-650nm) with the maxima at 413nm. The MSA coated NIR-emitting AuNPs showed a rapid fluorescence quenching toward Hg over other metal ions with a limit of detection (LOD, 3δ) as low as 4.8nM. The sensing mechanism investigation revealed that the AuNPs formed aggregation due to the "recognition" of Hg from the MSA, and the resultant strong coupling interaction between Hg and Au (I) to further quench the fluorescence of the AuNPs, which synergistically resulted in a highly sensitive and selective fluorescence response toward Hg. This proposed strategy was also demonstrated the possibility to be used for Hg detection in water samples.
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