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Risks associated with opioid prescriptions for headache in the emergency department.
Am J Emerg Med
January 2025
Departments of Emergency Medicine (EM) and Community Health Sciences, University of Calgary, Canada.
Study Hypothesis: Use of opioids for treatment of headache in the emergency department (ED) is associated with an increased 1-year risk of opioid-related adverse events.
Objective: To assess the safety and efficacy of opioid prescribing for ED patients with headache.
Methods: We performed a multicenter observational cohort study using linked administrative data.
Working effectively with individuals with substance use disorders: a qualitative descriptive study.
Br J Nurs
January 2025
Director, Practice Innovation, Standards and Measurement, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Background: Irrespective of where nurses work, they may provide care to individuals with substance use disorders. Unfortunately, some nurses may not understand how to work with these individuals and stigmatisation may occur.
Aim: To explore how to provide effective care for these individuals.
Alcohol Consumption and Autoimmune Diseases.
Int J Mol Sci
January 2025
Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.
Alcohol is the second-most misused substance after tobacco. It has been identified as a causal factor in more than 200 diseases and 5.3% of all deaths and is associated with significant behavioral, social, and economic difficulties.
View Article and Find Full Text PDFChanges in RNA Splicing: A New Paradigm of Transcriptional Responses to Probiotic Action in the Mammalian Brain.
Microorganisms
January 2025
State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School of Life Sciences, Yunnan University, Kunming 650091, China.
Elucidating the gene regulatory mechanisms underlying the gut-brain axis is critical for uncovering novel gut-brain interaction pathways and developing therapeutic strategies for gut bacteria-associated neurological disorders. Most studies have primarily investigated how gut bacteria modulate host epigenetics and gene expression; their impact on host alternative splicing, particularly in the brain, remains largely unexplored. Here, we investigated the effects of the gut-associated probiotic Lacidofil on alternative splicing across 10 regions of the rat brain using published RNA-sequencing data.
View Article and Find Full Text PDFAttitudes of Adolescents Toward Addictive Substances: Hope and Self-Control as Protective Factors.
Children (Basel)
January 2025
Department of Psychological Counseling and Guidance, Faculty of Education, Sakarya University, Sakarya 54050, Türkiye.
: Experiences of ostracism may be related to attitudes toward substance abuse. However, the protective factors underlying this relationship are still unclear. Therefore, based on the Need-threat and Self-control theory, we aimed to test a model in which self-control and hope mediate the relationship between ostracism and attitudes toward addictive substances.
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