renal-risk variants do not associate with incident cardiovascular disease or mortality in the Systolic Blood Pressure Intervention Trial.

Introduction: Relationships between apolipoprotein L1 gene () renal-risk variants (RRVs) and cardiovascular disease (CVD) remain controversial. To clarify associations between and CVD, 2,568 African American Systolic Blood Pressure Intervention Trial (SPRINT) participants were assessed for the incidence of CVD events (primary composite including non-fatal myocardial infarction, acute coronary syndrome not resulting in myocardial infarction, nonfatal stroke, non-fatal acute decompensated heart failure, and CVD death), renal outcomes, and all-cause mortality.

Methods: Cox proportional hazards regression models were employed adjusting for age, sex, African ancestry proportion, and treatment group (systolic blood pressure target of <120 mm Hg versus <140 mm Hg).

Results: Fourteen percent of participants had two RRVs; these individuals also had lower baseline estimated GFR and higher levels of albuminuria and BMI. After a median follow-up of 39 months, no significant association was observed between RRVs and the primary composite CVD outcome, any of its components, or all-cause mortality (recessive or additive genetic models). demonstrated a trend toward association with sustained 30% reduction in estimated GFR to <60 ml/min/1.73m in those with normal kidney function at baseline (hazard ratio [95% CI] 1.64 [0.85-2.93]; p=0.114, recessive model).

Conclusion: RRVs were not associated with incident CVD in high-risk hypertensive, non-diabetic African American participants in SPRINT.