We investigated the estimation accuracy of synaptic conductances by analyzing simulated voltage traces generated by a Hodgkin-Huxley type model. We show that even a single spike substantially deteriorates the estimation. We also demonstrate that two approaches, namely, negative current injection and spike removal, can ameliorate this deterioration.
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| http://dx.doi.org/10.1016/j.biosystems.2017.07.007 | DOI Listing |
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