AI Article Synopsis
- The study investigated the relationship between inflammation markers and visual health in patients with diabetic macular edema (DME) by measuring acute phase factors in their vitreous fluid.
- The research found higher levels of certain inflammation markers in DME patients compared to a control group, suggesting a link between these factors and eye health.
- Procalcitonin and fibrinogen levels were inversely related to visual acuity shortly after surgery but didn't correlate with retinal thickness or long-term visual outcomes.
Article Abstract
Purpose: Diabetic retinal maculopathy is associated with acute and chronic local inflammation. We measured the concentrations of acute phase factors in vitreous fluid of patients with diabetic macular edema (DME) and examined their relations to visual acuity and central retinal thickness (CRT) both before and after vitrectomy.
Study Design: Retrospective.
Methods: Vitreous fluid was collected during vitreoretinal surgery from 19 patients with DME and 12 control subjects with epiretinal membrane. The concentrations of acute phase factors (α2-macroglobulin, haptoglobin, C-reactive protein, serum amyloid P and A, procalcitonin, ferritin, tissue plasminogen activator, fibrinogen) and vascular endothelial growth factor (VEGF) were measured with multiplex assays. CRT of macular edema was measured by optical coherence tomography (OCT).
Results: The levels of serum amyloid P, procalcitonin, ferritin, and fibrinogen in vitreous fluid were increased in DME patients compared with control subjects. The levels of procalcitonin and fibrinogen in DME patients were inversely correlated with visual acuity both before and 3 months after vitrectomy but not 6 months postsurgery. The concentrations of these four factors were not correlated with either CRT or the vitreous levels of VEGF in DME patients.
Conclusion: Acute phase factors may contribute to local inflammation in DME and may therefore influence disease progression.
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| http://dx.doi.org/10.1007/s10384-017-0525-x | DOI Listing |
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