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Aggressive behavior complicates the presentation of many psychiatric illnesses, and is associated with significant morbidity. Antipsychotic medications are used to treat this symptom dimension across multiple diagnoses. In this meta-analysis we sought to identify the effect size of antipsychotic medications for the treatment of reactive-impulsive aggression in adults, and identify differences across underlying diagnosis and specific agent. A search was conducted of four databases, MEDLINE, PsychINFO, Embase and the Cochrane Library to end date of August 10, 2016. The search terms included "aggression", "irritable mood", "anger", "hostility" and "antipsychotic agents" or "dopamine antagonists". 505 results were found, of which 47 were reviewed in detail and 21 ultimately included in the analysis. Antipsychotics were broadly effective for the treatment of aggression, but with effect sizes similar to those for non-pharmacologic interventions (standard mean difference=0.29, 95% confidence interval 0.22-0.36, z=8.5, p<0.001). There was no evidence for differences according to choice of agent (χ=2.7, df=6, p=0.85), or conclusive evidence as to the importance of the underlying diagnosis (χ=3.2, df=3, p=0.36). A small but significant dose effect was identified (β=0.0002, 95% CI 0.0001-0.0004, p=0.038). Although antipsychotics appear to be effective for treatment of aggression, their small effect sizes in the context of their significant side-effects should be taken into account when making clinical decisions about their use.
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http://dx.doi.org/10.1016/j.pnpbp.2017.07.019 | DOI Listing |
Ann Ital Chir
March 2025
Breast Surgery Department, General Surgery Center, First Hospital of Jilin University, 130021 Changchun, Jilin, China.
Desmoid-type fibromatosis (DTF) is a rare and locally aggressive benign tumor affecting the breasts. It is characterized by infiltrative growth and local recurrence, though it cannot metastasize. We present the case of a woman in her early 20s diagnosed with a palpable mass within her right breast.
View Article and Find Full Text PDFAnn Ital Chir
March 2025
Department of General Surgery, Başakşehir Çam and Sakura City Hospital, 34480 İstanbul, Turkey.
Aim: This study aimed to investigate the relationship between the Cancer Inflammation Prognostic Index (CIPI) and microsatellite instability (MSI), tumor budding, and prognosis in colorectal cancer cases.
Methods: Patients with stage 1-3 colorectal cancer who underwent curative surgical treatment between May 2020 and January 2022 were included. Serum CIPI was calculated, a cut-off point was established using Receiver Operating Characteristic (ROC) analysis and Patients were divided into two groups according to their CIPI scores: Group 1 (low CIPI) consisted of 94 patients, and Group 2 (high CIPI) consisted of 95 patients.
J Matern Fetal Neonatal Med
December 2025
Department of Obstetrics and Gynecology, The First People's Hospital of Tianmen City, Tianmen City, Hubei Province, China.
Objective: To investigate the diagnostic efficacy and detection value of matrix metalloproteinase-9 (MMP-9) and VEGF in menacing pernicious placenta previa (PPP).
Method: Among all the cases of PPP, a critical condition within the Placenta Accreta Spectrum (PAS) caused by aberrant implantation of the placenta in the uterine wall, which were analyzed between April 2021 and March 2023, there were sixty-three cases. The control group consisted of those sixty-three women who had a normal placenta.
Ann Clin Lab Sci
January 2025
Department of Gastroenterology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China
Objective: Pancreatic adenocarcinoma (PAAD) is an aggressive and lethal cancer with limited treatment options and poor prognosis. Monoacylglycerol lipase (MGLL), a key enzyme in lipid metabolism, is thought to play a role in tumor progression, but its function in PAAD remains unclear. This study aims to investigate the expression and functional significance of MGLL in pancreatic cancer and evaluate melatonin (MLT) as a potential inhibitor of MGLL.
View Article and Find Full Text PDFJ Assoc Physicians India
March 2025
Professor, Department of Cardiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
Introduction: Percutaneous coronary intervention (PCI) with drug-eluting stents (DES) has transformed the management of coronary artery disease (CAD), particularly for single-vessel disease (SVD), by reducing restenosis rates. However, long-term survival data following PCI in North Indian populations are limited. This study aimed to evaluate survival and clinical outcomes after PCI with DES and identify factors associated with mortality and adverse events, such as chest pain, dyspnea, and bleeding.
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