AI Article Synopsis
- - The study aimed to explore the link between genetic variations (SNPs) in the ADRB2 gene and the likelihood of developing chronic obstructive pulmonary disease (COPD) in a Chinese population, involving 261 COPD patients and 239 healthy controls.
- - Analysis showed a significant association between the rs1042711 polymorphism in ADRB2 and increased COPD risk, with non-CC genotypes, particularly the TT genotype, leading to lower lung function measurements (FEV and FEV/FVC ratios).
- - The findings suggest that both the TT genotype at rs1042711 and a history of smoking are risk factors for developing COPD.
Article Abstract
Objective: This study was designed to investigate the association between single nucleotide polymorphisms (SNPs) of the β2-adrenergic receptor (ADRB2) gene and the risk of chronic obstructive pulmonary disease (COPD) in a Chinese population.
Methods: From January 2010 to October 2014, 261 COPD patients were selected as the case group and 239 healthy subjects were selected as the control group. Pulmonary function tests were performed to detect forced vital capacity (FVC), 1-s forced expiratory volume (FEV), and FEV/FVC (%). rs1042711, rs1042714, and rs1042718 were selected as tagSNPs of the ADRB2 gene from the HapMap database in accordance with previous studies. The ADRB2 genotypes were established by real-time polymerase chain reaction assays using TaqMan-labeled probes. The relationships between the ADRB2 polymorphisms and COPD risk were estimated using logistic regression analyses.
Results: The frequency of the genotypes and alleles of rs1042711 in ADRB2 showed a significant difference between the COPD and control groups (p < 0.05); compared with the CC genotype, the non-CC genotypes showed an increased COPD risk (p = 0.002). Compared with the CC haplotype, the TG haplotype increased COPD risk, while the CG haplotype reduced COPD risk for normal individuals. Compared with the CC genotype, the TT genotype showed significantly lower FEV and FEV/FVC (p = 0.022, p = 0.0191, respectively). Both the TC and TG haplotypes showed lower FEV and FEV/FVC in comparison with the CC haplotype (both p < 0.05). The results of logistic regression analysis showed that rs1042711 of ADRB2 and smoking history were associated with COPD risk (both p < 0.05).
Conclusion: It is indicated that the TT genotype of rs1042711 and smoking pack years are both risk factors for COPD.
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| http://dx.doi.org/10.1089/gtmb.2017.0030 | DOI Listing |
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