AI Article Synopsis
- - Preeclampsia is a serious complication during pregnancy linked to abnormal formation of the placenta, caused by insufficient invasion of cells that normally promote healthy blood flow to the placenta.
- - The study investigates differences in vimentin protein, which is important for cell structure and other functions, in the placentas of women with preeclampsia compared to those with normal pregnancies.
- - Eight different forms of vimentin were identified, with specific lower weight fragments found to be significantly higher in women with preeclampsia, indicating altered protein processing in this condition.
Article Abstract
Preeclampsia is a pregnancy complication that is the result of abnormal placentation because of inadequate trophoblast invasion into spiral arteries that prevent normal blood flow to the placenta. We report the alteration in vimentin protein proteolysis in placenta of normotensive and preeclamptic women, which is known to have a role in many physiological functions other than its major function in the structural integrity of the cell. Placental proteome from normotensive (n = 25) and preeclamptic pregnancies (n = 25) showed eight differentially accumulated protein spots of vimentin (proteolytic fragments) by two-dimensional electrophoresis. Immunoblots of normotensive and preeclamptic placenta revealed a difference in proteolytic processing of vimentin. In particular, lower molecular weight vimentin fragments of 32 and 20 kDa were 3.3 and 2.6-fold (p < 0.0001) higher, respectively, in preeclampsia compared with normotensive placenta.
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| http://dx.doi.org/10.1002/cm.21390 | DOI Listing |
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