Sixteen compounds, including two new natural products ( and ), were obtained from the twigs of . The structures were elucidated based on NMR, MS, IR data and optical rotation values. Compounds , , and displayed moderate antibacterial activities against clinical isolates; compounds , , , and protected neural cells against oxidative stress; and compounds and exhibited anti-acetylcholinesterase activity.
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http://dx.doi.org/10.1016/j.apsb.2017.06.002 | DOI Listing |
Wiad Lek
January 2025
DEPARTMENT OF PHARMACOLOGY AND TOXICOLOGY, FACULTY OF PHARMACY, UNIVERSITY OF KUFA, KUFA, IRAQ.
Objective: Aim: Testing Cordia myxa extract on colon cancer cell line and caspase-3 gene and COX-2 protein expression.
Patients And Methods: Materials and Methods: This study used Cordia myxa ethanolic extract at various dosages on SW480 cells. Cell proliferation was measured using MTT, also examined effect of Cordia myxa extract on caspase-3 gene expression using quantitative real-time polymerase chain reaction.
Chem Biodivers
January 2025
Department of Pharmaceutical Sciences, College of Health Sciences and Pharmacy, Chicago State University, Chicago, Illinois, USA.
This study was undertaken to assess the antioxidant and neuropharmacological potentials of the methanol leaf extract of Acanthus ebracteatus (MAEL) through experimental and in silico methods. The phytochemical screening (PS) and GC-MS (gas chromatography-mass spectrometry) identified 28 phytochemicals with different classes in nature in MAEL. The MAEL revealed better antioxidant activity through various in vitro antioxidant assays.
View Article and Find Full Text PDFAMB Express
January 2025
Department of Agriculture Economics, Faculty of Agriculture, Ain Shams University, Cairo, 11241, Egypt.
The urgent need to address the growing problem of antimicrobial resistance in multidrug-resistant bacteria requires the development of pioneering approaches to treatment. The present study aims to evaluate the antimicrobial potential of the essential oils (EOs) of Moringa oleifera (moringa), Cinnamomum verum (cinnamon), and Nigella sativa (black seed) and the synergistic effect of the mixture of these oils against Staphylococcus aureus MCC 1351. Statistical modeling revealed cinnamon oil had the highest individual antimicrobial potency, followed by black seed oil.
View Article and Find Full Text PDFNat Prod Res
January 2025
Krishna Institute of Pharmacy, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, India.
Linn., commonly known as the 'Tree of Sadness' belongs to Oleaceae family. In Ayurvedic, Siddha, Unani, and Homeopathic therapeutic systems, it has been used to treat various conditions, including ulcers, skin diseases, hair loss, piles, liver diseases, rheumatism, and malarial fevers.
View Article and Find Full Text PDFNEJM Evid
February 2025
DURECT Corporation, Cupertino, CA.
Background: Larsucosterol is a DNA methyltransferase inhibitor in development for alcohol-associated hepatitis (AH), a disease for which there is no approved therapy.
Methods: In this phase 2b trial, patients with severe AH were randomly assigned 1:1:1 to receive 30 mg or 90 mg of larsucosterol or placebo; a second dose was administered after 72 hours if the patient remained hospitalized. All patients received supportive care as determined by investigators.
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