Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Antileishmanial and Antitrypanosomal Trends of Synthetic Tetralone Derivatives.
Drug Dev Res
February 2025
Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Aljouf, Saudi Arabia.
Leishmaniasis and trypanosomiasis are parasitic diseases that are closely linked to poverty, pose significant local burdens, and are common in tropical and subtropical regions. Various synthetic tetralone derivatives were studied as potential scaffolds for antileishmanial and antitrypanosomal activities. The compounds were studied for their effectiveness against multiple kinetoplastid protozoan pathogens: Leishmania major, Leishmania mexicana, and bloodstream trypomastigotes of Trypanosoma brucei brucei.
View Article and Find Full Text PDFEfficacy of a high dose of isometamidium chloride treatment in single and mixed experimental infections with T. congolense and T. brucei brucei in dogs.
Comp Immunol Microbiol Infect Dis
January 2025
Department of Veterinary Parasitology and Entomology, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Enugu State, Nigeria.
Canine African trypanosomosis is endemic in sub-Saharan Africa. Chemotherapy remains the commonly employed approach to trypanosomosis control. However, it is beleaguered by the absence of new drugs, treatment failures, relapse infection and resistance.
View Article and Find Full Text PDFIsolation and Total Synthesis of Ukabamide, an Antitrypanosomal Lipopeptide from a Marine sp. Cyanobacterium.
Org Lett
January 2025
Department of Chemistry, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan.
Human African trypanosomiasis (HAT) is one of the most lethal of the neglected tropical diseases. While the discovery of a novel antitrypanosomal drug is highly desired, the creation of a superior lead compound is challenging. Herein we report ukabamide (), which was isolated from a marine sp.
View Article and Find Full Text PDF3'-deoxytubercidin: A potent therapeutic candidate for the treatment of Surra and Dourine.
Int J Parasitol Drugs Drug Resist
January 2025
Laboratory of Microbiology, Parasitology and Hygiene, Infla-Med Centre of Excellence, University of Antwerp, 2610, Wilrijk, Belgium. Electronic address:
Surra and Dourine are widespread diseases caused by two protozoan parasites Trypanosoma brucei evansi and Trypanosoma brucei equiperdum, respectively. A wide range of animals including camels, horses, cattle and buffaloes are susceptible to infection. These diseases pose a significant socio-economic burden, primarily due to the limited therapeutic options and the complications associated with toxicity and drug resistance, making disease management particularly challenging.
View Article and Find Full Text PDFAntiparasitic Activities of Plants From the Traditional Senegalese Pharmacopoeia: Isolation of Antitrypanosomal and Antileishmanial Ellagic Acid Derivatives From Terminalia Avicennioides.
Chem Biodivers
January 2025
Joint Research Unit 1158 BioEcoAgro, Univ. Lille, Junia, INRAE, Univ. Liège, UPJV, Univ. Artois, ULCO, Lille, France.
Parasitic diseases such as trypanosomiasis and leishmaniasis pose significant health challenges in Africa. The Senegalese Pharmacopoeia, known for its many medicinal plants with anti-infectious properties, can be a source of antiparasitic natural products. This study aimed to evaluate the in vitro antiparasitic activities of 33 methanolic extracts from 24 ethnopharmacologically selected plants against Trypanosoma brucei brucei (Tbb) and Leishmania mexicana mexicana (Lmm), as well as their cytotoxic activities on WI-38 cells.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!