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Bacterial Nanovesicles as Interkingdom Signaling Moieties Mediating Pain Hypersensitivity.
ACS Nano
January 2025
Department of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, United States.
Gut dysbiosis contributes to multiple pathologies, yet the mechanisms of the gut microbiota-mediated influence on systemic and distant responses remain largely elusive. This study aimed to identify the role of nanosized bacterial extracellular vesicles (bEVs) in mediating allodynia, i.e.
View Article and Find Full Text PDFCoixol-Loaded Hydrogels Promote Osteochondral Defect Repair via Modulation of Ferroptosis and Autophagy in Chondrocytes.
ACS Biomater Sci Eng
January 2025
The Affiliated Ganzhou Hospital of Nanchang University, Meiguan Avenue No. 16, Ganzhou 341000, China.
Osteoarthritis (OA) is a chronic multifactorial disease characterized by cartilage degeneration, pain, and reduced mobility. Current therapies primarily aim to relieve pain and restore function, but they often have limited effectiveness and side effects. Coixol, a bioactive compound from Coix lacryma-jobi L.
View Article and Find Full Text PDFLactation, mastitis, and probiotics.
Arch Argent Pediatr
January 2025
Instituto de Lactología Industrial (INLAIN, CONICET-UNL), Faculty of Chemical Engineering, Universidad Nacional del Litoral, Santa Fe, Argentina.
Exclusive breastfeeding during the first six months of life, and prolonged with complementary feeding until 2 years of age or more, is the best nutritional approach in the first stage of life. Mastitis is a pathology that can jeopardize the continuity of breastfeeding. Different methods have been proposed for the prevention and treatment of mastitis, including probiotics.
View Article and Find Full Text PDFECG Patterns of Occlusion Myocardial Infarction: A Narrative Review.
Ann Emerg Med
January 2025
Department of Emergency Medicine, University of Minnesota, Minneapolis, MN; Department of Emergency Medicine, Hennepin Healthcare, Minneapolis, MN.
The traditional management of acute coronary syndrome has relied on the identification of ST-segment elevation myocardial infarction (STEMI) as a proxy of acute coronary occlusion. This conflation of STEMI with acute coronary occlusion has historically overshadowed non-ST-segment elevation myocardial infarction (NSTEMI), despite evidence suggesting 25% to 34% of NSTEMI cases may also include acute coronary occlusion. Current limitations in the STEMI/NSTEMI binary framework underscore the need for a revised approach to chest pain and acute coronary syndrome management.
View Article and Find Full Text PDFEstimating the Proportion of Telehealth-Able United States Emergency Department Visits.
Ann Emerg Med
January 2025
Department of Emergency Medicine Massachusetts General Hospital, Boston, MA. Electronic address:
Study Objective: We use national emergency department (ED) data to identify the proportion of "telehealth-able" ED visits, defined as potentially conductible by Video Only or Video Plus (with limited outpatient testing).
Methods: We used ED visits by patients 4 years of age and older from the 2019 National Hospital Ambulatory Medical Care Survey and applied survey weighting for national representativeness. Two raters categorized patient-described Reasons for Visit (RFV) as telehealth-able (yes, no, uncertain) for both Video Only and Video Plus visits.
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