Introduction: Dental caries is defined as a pathological breakdown of the tooth. It is an infectious phenomenon involving a multifactorial aetiology. The impact of drugs on cariogenic risk has been poorly investigated.
Objectives: In this study, we identified drugs suspected to induce dental caries as adverse drug reactions (ADRs) and then studied a possible pathogenic mechanism for each drug that had a statistically significant disproportionality.
Methods: We extracted individual case safety reports of dental caries associated with drugs from VigiBase (the World Health Organization global individual case safety report database). We calculated disproportionality for each drug with a reporting odds ratio (ROR) and 99% confidence interval. We analysed the pharmacodynamics of each drug that had a statistically significant disproportionality.
Results: In VigiBase, 5229 safety reports for dental caries concerning 733 drugs were identified. Among these drugs, 88 had a significant ROR, and for 65 of them (73.9%), no information about dental caries was found in the summaries of the product characteristics, the Micromedex DRUGDEX, or the Martindale databases. Regarding the pharmacological classes of drugs involved in dental caries, we identified bisphosphonates, atropinic drugs, antidepressants, corticoids, immunomodulating drugs, antipsychotics, antiepileptics, opioids and β-adrenoreceptor agonist drugs. Regarding possible pathogenic mechanisms for these drugs, we identified changes in salivary flow/composition for 54 drugs (61.4%), bone metabolism changes for 31 drugs (35.2%), hyperglycaemia for 32 drugs (36.4%) and/or immunosuppression for 23 drugs (26.1%). For nine drugs (10.2%), the mechanism was unclear.
Conclusion: We identified 88 drugs with a significant positive disproportionality for dental caries. Special attention has to be paid to bisphosphonates, atropinic drugs, immunosuppressants and drugs causing hyperglycaemia.
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http://dx.doi.org/10.1007/s40264-017-0575-5 | DOI Listing |
Community Dent Oral Epidemiol
January 2025
School of Clinical Dentistry, University of Sheffield, Sheffield, UK.
Objectives: Supervised toothbrushing programmes (STPs), whereby children brush their teeth at nursery or school with a fluoride toothpaste under staff supervision, are a clinically and cost-effective intervention to reduce dental caries. However, uptake is varied, and the reasons unknown. The aim was to use an implementation science approach to explore the perspectives of key stakeholders on the barriers and facilitators at each level of implementation of STPs.
View Article and Find Full Text PDFCureus
December 2024
College of Dentistry, King Saud bin Abdulaziz University for Health Sciences, Riyadh, SAU.
Pediatric dental health is critically impacted by enamel demineralization and early-stage caries, with remineralization therapies playing a vital role in preventing progression. This systematic review evaluates the effectiveness of various delivery methods for remineralization agents in pediatric patients aged 3-15 years, focusing on varnishes, gels, foams, and sprays. Studies were included if they were randomized controlled trials (RCTs), cohort studies, or case-control studies involving pediatric patients with early-stage caries or enamel demineralization, while studies with non-pediatric populations, unrelated treatments, or significant methodological flaws were excluded.
View Article and Find Full Text PDFFront Oral Health
January 2025
Department of General Dentistry, School of Dental Medicine, Stony Brook University, Stony Brook, NY, United States.
Introduction: Previous studies have shown () esterase is a key mediator of dental composite biodegradation, which can contribute to recurrent caries. This study is to investigate the inhibitory effects of a novel Chemically-Modified-Curcumin (CMC 2.24) on esterase activities and related dental material biodegradation.
View Article and Find Full Text PDFJ Med Life
December 2024
Department of Population Health, School of Health Sciences, Hofstra University, Hempstead, New York, USA.
This study explored the role of dentate status and dental caries on diabetes-related complications among patients with type 2 diabetes mellitus (T2DM). A hospital-based cross-sectional design was applied to collect data on diabetic patients attending integrated services for non-communicable diseases and oral health at a public hospital in Thailand. Diabetic complication outcomes included diabetic eye and foot complications and chronic kidney disease (CKD).
View Article and Find Full Text PDFFront Med (Lausanne)
January 2025
School of Health Sciences, The University of Newcastle, Callaghan, NSW, Australia.
Aims: This study aims to evaluate salivary alpha-amylase levels in children diagnosed with Early Childhood Caries (ECC) and Rampant Caries (RC) and compare them to levels in children without ECC or RC. It also examines the relationship between salivary alpha-amylase levels and increased caries activity in the children with ECC or RC.
Materials And Methods: A cross-sectional study was conducted at RAK College of Dental Sciences (RAKCODS) with 100 children aged 3-12 years.
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