AI Article Synopsis

  • * The sensor features two rows of stretchable electrodes on an inflatable balloon, allowing for deep penetration into arteries to assess lipid levels using alternating current (AC) and analyze specific impedance profiles.
  • * Our studies in a rabbit model of atherosclerosis demonstrated that these impedance mappings can successfully detect early stages of disease, potentially aiding in the prevention of serious conditions like heart attacks or strokes.

Article Abstract

We designed a novel 6-point electrochemical impedance spectroscopy (EIS) sensor with 15 combinations of permutations for the 3-D mapping and detection of metabolically active atherosclerotic lesions. Two rows of 3 stretchable electrodes circumferentially separated by 120° were mounted on an inflatable balloon for intravascular deployment and endoluminal interrogation. The configuration and 15 permutations of 2-point EIS electrodes allowed for deep arterial penetration via alternating current (AC) to detect varying degrees of lipid burden with distinct impedance profiles (Ω). By virtue of the distinctive impedimetric signature of metabolically active atherosclerotic lesions, a detailed impedance map was acquired, with the 15 EIS permutations uncovering early stages of disease characterized by fatty streak lipid accumulation in the New Zealand White rabbit model of atherosclerosis. Both the equivalent circuit and statistical analyses corroborated the 3-D EIS permutations to detect small, angiographically invisible, lipid-rich lesions, with translational implications for early atherosclerotic disease detection and prevention of acute coronary syndromes or strokes.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525747PMC
http://dx.doi.org/10.7150/thno.19184DOI Listing

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