AI Article Synopsis
- This study investigates the vibration profiles of neuronal cells and brain tumor tissues using a novel contact-free method that transforms an atomic force microscope into a sensitive microphone.
- The research found a vibration frequency of 3.4 Hz in cultured rat hippocampal neurons, with the ability to change this frequency through pharmacological interventions.
- The study also highlighted that malignant astrocytoma tissues exhibited distinct vibration patterns compared to meningioma and neocortical tissues, allowing for real-time differentiation among these tissue types through acoustic analysis.
Article Abstract
This study reports vibration profiles of neuronal cells and tissues as well as brain tumor and neocortical specimens. A contact-free method and analysis protocol was designed to convert an atomic force microscope into an ultra-sensitive microphone with capacity to record and listen to live biological samples. A frequency of 3.4 Hz was observed for both cultured rat hippocampal neurons and tissues and vibration could be modulated pharmacologically. Malignant astrocytoma tissue samples obtained from operating room, transported in artificial cerebrospinal fluid, and tested within an hour, vibrated with a much different frequency profile and amplitude, compared to meningioma or lateral temporal cortex providing a quantifiable measurement to accurately distinguish the three tissues in real-time. Vibration signals were converted to audible sound waves by frequency modulation, thus demonstrating, acoustic patterns unique to meningioma, malignant astrocytoma and neocortex.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525746 | PMC |
| http://dx.doi.org/10.7150/thno.19172 | DOI Listing |
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