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Use of Topical Insulin to Treat Refractory Neurotrophic Corneal Ulcers. | LitMetric

Use of Topical Insulin to Treat Refractory Neurotrophic Corneal Ulcers.

Cornea

*Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI; †McPherson Eye Research Institute, University of Wisconsin-Madison, Madison, WI; and ‡Waisman Center, University of Wisconsin-Madison, Madison WI.

Published: November 2017

AI Article Synopsis

Article Abstract

Purpose: To report the clinical course of 6 patients with refractory neurotrophic corneal ulcers that were treated with topical insulin drops.

Methods: Retrospective chart review of patients who had neurotrophic corneal ulcers or epithelial defects refractory to standard medical and surgical treatment. Insulin drops, prepared by mixing regular insulin in artificial tears with a polyethylene glycol and propylene glycol base at a concentration of 1 unit per milliliter, were prescribed 2 to 3 times daily.

Results: Six patients, aged 2 to 73 years, developed neurotrophic corneal ulcers refractory to a range of medical and surgical treatments, including bandage contact lens, amniotic membrane grafting, and permanent tarsorrhaphy. Each patient was administered topical insulin drops with complete corneal reepithelialization within 7 to 25 days.

Conclusions: Topical insulin may be a simple and effective treatment for refractory neurotrophic corneal ulcers. Further study is required to determine the clinical efficacy and side effect profile of insulin drops.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633504PMC
http://dx.doi.org/10.1097/ICO.0000000000001297DOI Listing

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