Acromegaly is a serious disease that affects the pituitary gland causing unusual growth in patients. There are various dental manifestation of the condition and it is plausible that a dentist will be the first to recognize the problem. This article describes the disease and the dental implications for patients who have it.
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Endoscopic Transsphenoidal Surgery in Growth-Hormone Pituitary Adenomas (GH PitNETs): Current Indications, Limitations, and the Importance of a Multidisciplinary Approach.
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Acromegaly and gigantism are rare diseases, usually caused by a growth hormone-secreting pituitary adenoma, recently renamed GH-secreting pituitary neuroendocrine tumor (GH-PitNET). The transsphenoidal approach is the mainstay of treatment, although a non-negligible number of patients require a multimodal approach with neo-adjuvant or adjuvant medical and radiation therapy. Understanding the clinical complexity of acromegaly and gigantism is essential to improve treatment safety and success.
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[This corrects the article on p. 421 in vol. 52, PMID: 36605861.
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Article Synopsis
- - Somatostatin is a peptide with multifaceted roles as a neurotransmitter and endocrine regulator, primarily exerting inhibitory effects in various tissues, despite its low physiological concentrations.
- - It binds to specific receptors called somatostatin receptors (SSTRs), which differ in tissue distribution and can be altered in conditions like tumors, making them useful as cancer biomarkers and for prognostic insights.
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