AI Article Synopsis
- The study examined blood levels of HMGB-1 in neonates with hypoxic-ischemic encephalopathy (HIE) treated with brain/body hypothermia (BHT).
- The BHT (+) group showed higher initial HMGB-1 levels, which decreased significantly and reached normal levels by 2 days of age.
- Higher HMGB-1 levels in the BHT (+) group were associated with worse neurological outcomes, indicating that HMGB-1 levels could help assess the need for BHT and predict short-term outcomes.
Article Abstract
Background: We measured changes in the blood level of high-mobility group box-1 (HMGB-1) at 24 h intervals in neonates treated with brain/body hypothermia (body hypothermia therapy: BHT) for hypoxic-ischemic encephalopathy (HIE), to evaluate the usefulness of HMGB-1 level for determining outcomes.
Methods: We studied 15 neonates with HIE who underwent BHT (BHT (+) group) and six neonates with HIE who did not (BHT (-) group). We recorded HMGB-1 changes at 24 h intervals, creatinine phosphokinase, and the resistance index of the anterior cerebral artery. Magnetic resonance imaging (MRI) was used to determine short-term outcome.
Result: Baseline HMGB-1 was significantly higher in the BHT (+) group than in the BHT (-) group. Thereafter, HMGB-1 in the BHT (+) group significantly decreased at 24 h intervals, reaching the reference range by 2 days of age. In the BHT (+) group, when patients were classified into clinically significant neurological disorder due to HIE (+) and (-) according to MRI, the neurological disorder (+) group had higher mean HMGB-1.
Conclusions: In HIE, HMGB-1 differs according to the presence of BHT, suggesting that HMGB-1 measurement soon after birth might be useful for determining BHT necessity and short-term outcome.
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| http://dx.doi.org/10.1111/ped.13377 | DOI Listing |
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