AI Article Synopsis
- - Cancer genomes show a range of somatic alterations that vary significantly between different cancer types and among individuals with the same type.
- - Many of these alterations disable normally functioning genes; however, due to genetic redundancy, they don't negatively affect cancer cells.
- - Understanding these cancer-specific dependencies can be used to develop targeted therapies for treatment.
Article Abstract
Cancer genomes acquire somatic alterations that largely differ between and within cancer types. Several of these alterations inactivate genes that are normally functional with no deleterious consequences on cancer cells due to genetic redundancy. Here we discuss how this leads to cancer synthetic dependencies that can be exploited in therapy.
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| http://dx.doi.org/10.1016/j.trecan.2016.03.003 | DOI Listing |
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