Tuning the redox potential of vitamin K derivatives by oxidative functionalization using a Ag(i)/GO catalyst.

We propose herein initial results to develop optimum redox mediators by the combination of computational simulation and catalytic functionalization of the core structure of vitamin K. We aim to correlate the calculated energy value of the LUMO of different vitamin K derivatives with their actual redox potential. For this, we optimized the catalytic alkylation of 1,4-naphthoquinones with a designed Ag(i)/GO catalyst and synthesized a series of molecules.