Transient osteoporosis of the hip with a contralateral delayed involvement: a case report.

Clin Cases Miner Bone Metab

Department of Orthopaedic and Trauma Surgery, "Magna Græcia" University, "Mater Domini" University Hospital, Catanzaro, Italy.

Published: May 2017

AI Article Synopsis

  • The case discusses a male patient experiencing non-simultaneous bilateral hip pain with bone marrow edema, where the second hip was affected 12 years after the initial symptoms.
  • After thorough clinical evaluation and imaging, the condition was diagnosed as metachronous bilateral transient osteoporosis of the hip (TOH), a rare occurrence.
  • This specific instance of TOH with 12 years between hip involvement is unprecedented in medical literature.

Article Abstract

We describe a case of non-simultaneous bilateral hip pain with bone marrow edema occurring in an adult male, with the contralateral hip being involved 12 years later after the onset of symptoms. On the basis of clinical and imaging findings, together with a complete resolution after conservative management, a post-hoc diagnosis of metachronous bilateral transient osteoporosis of the hip (TOH) was made. Non-simultaneous bilateral presentation of TOH is exceptional, and contralateral involvement with a 12-year delay has never been previously described.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505719PMC
http://dx.doi.org/10.11138/ccmbm/2017.14.1.083DOI Listing

Publication Analysis

Top Keywords

transient osteoporosis
8
osteoporosis hip
8
non-simultaneous bilateral
8
hip
4
hip contralateral
4
contralateral delayed
4
delayed involvement
4
involvement case
4
case report
4
report describe
4

Similar Publications

Article Synopsis
  • Transient osteoporosis (TO) is a temporary bone condition that commonly occurs in the third trimester of pregnancy, characterized by knee pain in some cases.
  • A case study of a 38-year-old pregnant woman showed significant knee pain for 8 weeks, diagnosed as TO, which resolved completely within a few months.
  • Healthcare providers should consider TO as a possible diagnosis for knee pain in pregnant women.
View Article and Find Full Text PDF

TMEM16A, a key calcium-activated chloride channel, is crucial for many physiological and pathological processes such as cancer, hypertension, and osteoporosis, etc. However, the regulatory mechanism of TMEM16A is poorly understood, limiting the discovery of effective modulators. Here, we unveil an allosteric gating mechanism by presenting a high-resolution cryo-EM structure of TMEM16A in complex with a channel inhibitor that we identified, Tamsulosin, which is resolved at 2.

View Article and Find Full Text PDF

Atraumatic bilateral femoral neck fractures are rare, especially in younger patients and those without significant comorbidities. However, pregnant individuals appear to be at increased risk due to normal physiological changes in calcium balance, leading to transient osteoporosis of the hip. In these individuals, calcium and bone mineral density are generally decreased, reflecting the calcium demands of the developing fetus.

View Article and Find Full Text PDF

Transient osteoporosis of the hip in pregnancy.

Obstet Med

February 2024

Department of Obstetric Medicine, Laval University, Quebec, Canada.

Transient osteoporosis of the hip is an uncommon bone marrow oedema syndrome of unknown pathophysiology affecting previously healthy pregnant women and young to middle-aged men. The disorder is characterised by hip pain, reduced mobility, and the risk of fracture, which is significantly higher in pregnant than in non-pregnant individuals. Diagnosis is by magnetic resonance imaging.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!