AI Article Synopsis
- Recent studies show that common fragile sites (CFSs), once thought to cause chromosome rearrangements in cancers, are not commonly involved in major translocations or rearrangements.
- There's been a shift in focus to understanding how CFS instability contributes to genome instability and affects cancer development.
- New findings highlight that CFSs can lead to specific copy number changes, impacting the genetic makeup of various cancers.
Article Abstract
Ever since initial suggestions that instability at common fragile sites (CFSs) could be responsible for chromosome rearrangements in cancers, CFSs and associated genes have been the subject of numerous studies, leading to questions and controversies about their role and importance in cancer. It is now clear that CFSs are not frequently involved in translocations or other cancer-associated recurrent gross chromosome rearrangements. However, recent studies have provided new insights into the mechanisms of CFS instability, their effect on genome instability, and their role in generating focal copy number alterations that affect the genomic landscape of many cancers.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546318 | PMC |
| http://dx.doi.org/10.1038/nrc.2017.52 | DOI Listing |
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