AI Article Synopsis
- The study aimed to determine whether pathological response or metabolic response is a stronger predictor of survival in patients with thoracic esophageal squamous cell carcinoma treated with neoadjuvant chemoradiotherapy and surgery.
- Fifty patients were analyzed, revealing that 20% achieved a pathological complete response while 72% had a significant pathological response; both pathological and metabolic responses were found to significantly influence 3-year survival.
- The results indicated that metabolic response is a more powerful and independent predictor of survival compared to pathological response, alongside gender as a significant factor.
Article Abstract
Aim: We investigated which is the stronger predictor, pathological response or metabolic response, for survival outcome in patients treated with neoadjuvant chemoradiotherapy (NACRT) plus esophagectomy for thoracic esophageal squamous cell carcinoma (TESCC).
Patients And Methods: Fifty consecutive patients with cStage IIB-IV TESCC were enrolled. We analyzed the pathological response and metabolic response (fractional decrease in tumor maximum standardized uptake value) to NACRT. Independent prognostic factors predictive of 3-year survival were investigated using univariate and multivariate analyses.
Results: Among the 50 patients, 10 (20%) showed a pathological complete response (in both tumor and lymph nodes) and 36 (72%) showed grade 2-3 pathological response. Univariate analysis showed that age, gender, cT stage, pathological response and metabolic response to be significant prognostic factors. A subsequent multivariate analysis confirmed metabolic response and gender to be significant prognostic factors.
Conclusion: Metabolic response for NACRT was an independent prognostic factor and a more powerful predictor of survival compared to pathological response.
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| http://dx.doi.org/10.21873/anticanres.11808 | DOI Listing |
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