Background: This study aims at evaluating the influence of platelet count, platelet mass index, and platelet function on the spontaneous closure of ductus arteriosus in prematurity.
Methods: All preterm babies were divided into two groups, including Group 1 with "open PDA" and Group 2 with "closed PDA". The variables of platelet count, mean platelet volume, platelet mass index, and platelet function were analyzed and compared between two groups of patients to identify the factors that significantly influenced spontaneous closure of ductus arteriosus.
Results: Twenty-four patients were in the "open PDA" group, whereas 36 patients were in the "closed PDA" group. Mean GA and BW were 27.6 ± 1.8 (23.1-30.4) and 28 ± 1.6 (23.4-30.6) weeks and 1009 ± 270 (585-1480) g and 1035 ± 298 (505-1500) g in "open PDA" and "closed PDA" groups, respectively (p > 0.05). The incidence of "Collagen-ADP > 130 s" was significantly higher in the "open PDA" group, and the levels of hemoglobin and hematocrit were significantly lower in the "open PDA" group (p < 0.05). Multivariate logistic regression analysis showed that respiratory distress syndrome (OR: 9, CI: 1.5-51.8) and collagen-ADP > 130 s (OR: 5.7 CI: 1.55-21.3) are two independent factors associated with ductal patency.
Conclusion: This is the first study in the English literature providing evidence of the influence of platelet dysfunction on the spontaneous closure of ductus arteriosus in prematurity. Longer collagen-ADP duration is identified as a risk factor of ductal closure.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.pedneo.2017.01.006 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effect of Antenatal Magnesium Sulfate Exposure on Patent Ductus Arteriosus in Premature Infants.
Am J Perinatol
September 2024
Division of Neonatology, Department of Pediatrics, Ankara University Faculty of Medicine, Ankara, Türkiye.
Article Synopsis
- - The study aimed to explore the relationship between antenatal magnesium sulfate (MgSO) exposure and the occurrence of patent ductus arteriosus (PDA) in preterm infants, particularly those born between 24 and 31 weeks of gestation.
- - Results showed that while antenatal MgSO exposure was linked to a higher risk of hemodynamically significant PDA (hsPDA), it did not influence the rates of PDA ligation or the presence of open PDA at discharge.
- - The findings suggest that high doses of MgSO (over 20g) might increase hsPDA risk, but more research is necessary to clarify how the dosage impacts these outcomes.
An Observational, Prospective, Multicenter, Registry-Based Cohort Study Comparing Conservative and Medical Management for Patent Ductus Arteriosus.
Front Pediatr
July 2020
Division of Neonatology, Department of Pediatrics, Ankara University School of Medicine, Ankara, Turkey.
Article Synopsis
- * It found that 46% of the infants had moderate-to-large PDA, with 24% managed conservatively and 76% receiving medical treatment, revealing no significant differences in severe complications or surgical needs between the two groups.
- * Notably, medical treatment raised the risk of mortality but lowered the chances of bronchopulmonary dysplasia (BPD) or death, with ibuprofen and paracetamol being the most common treatments; however, early treatment (before day
A promising, novel index in the diagnosis and follow-up of patent ductus arteriosus: Red cell distribution width-to-platelet ratio.
J Clin Lab Anal
November 2018
Division of Neonatology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
Background: The role of red cell distribution width-to-platelet ratio (RPR) has not previously been mentioned in reports on patent ductus arteriosus (PDA). Our objective was to evaluate whether RPR would have a role in the diagnosis and/or prediction of pharmacological closure of PDA.
Methods: Preterm infants' gestational age ≤30 weeks and ≤1500 g who were given first ibuprofen treatment in the first week of life for hemodynamically significant PDA (hsPDA) were included in the study.
Influence of platelet count, platelet mass index, and platelet function on the spontaneous closure of ductus arteriosus in the prematurity.
Pediatr Neonatol
February 2018
Ankara University, School of Medicine, Department of Pediatrics, Division of Pediatric Cardiology, Ankara, Turkey.
Background: This study aims at evaluating the influence of platelet count, platelet mass index, and platelet function on the spontaneous closure of ductus arteriosus in prematurity.
Methods: All preterm babies were divided into two groups, including Group 1 with "open PDA" and Group 2 with "closed PDA". The variables of platelet count, mean platelet volume, platelet mass index, and platelet function were analyzed and compared between two groups of patients to identify the factors that significantly influenced spontaneous closure of ductus arteriosus.
Construction of Ductal Diameter Centiles in the First 24 h of Life and Their Relation to Cerebral Blood Flow in Neonates Weighing Less Than 1250 g in the First 24 h of Life.
J Trop Pediatr
December 2017
Department of Neonatology, Fernandez Hospital, Hyderabad, Telangana 500029, India.
Aims And Objectives: To evaluate the ductal diameter centiles in the first 24 h of life and their relation to cerebral blood flow in neonates weighing <1250 g in the first 24 h of life.
Method And Material: This prospective observational cohort study enrolled 44 infants with birth weight <1250 g. Two-dimensional echocardiography and color Doppler were performed within the first 12 h of life and were repeated again in the next 12 h of life to assess the ductal size and middle cerebral artery (MCA) flows [peak systolic velocity (PSV), end diastolic velocity (EDV), mean velocity (MV) and pulsatility index (PI)].
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!