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| http://dx.doi.org/10.1089/hs.2017.0058 | DOI Listing |
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Severe anemia predisposes very premature infants to transfusion-associated necrotizing enterocolitis.
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Boston Children's Health Physicians, New York Medical College, Valhalla, NY, USA; Global Newborn Society, Clarksville, MD, USA; Banaras Hindu University Institute of Eminence, Varanasi, India. Electronic address:
Necrotizing enterocolitis (NEC) is a catastrophic inflammatory bowel necrosis of premature infants. The etiology is unknown, but 25-40 % of cases have a history of red blood cell (RBC) transfusions in the preceding 48 h. This association has been noted in retrospective case/case-control studies, and many meta-analyses, and in a murine model.
View Article and Find Full Text PDFManaging Complex Hepatocellular Carcinoma Subtypes: Diffuse Infiltrative, Large Tumours, and Tumour Rupture-The Challenges and Strategies.
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Department of Gastroenterology, Liver Centre, Asan Medical Centre, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Hepatocellular carcinoma (HCC) is the sixth most common cause of cancer globally, third most common cause of cancer-related death, and most common primary liver malignancy. Whilst nodular well-defined HCC remains the classical phenotype, presentations with infiltrative phenotype, very large HCC, and complications as tumour rupture provide immense diagnostic and therapeutic challenges. Infiltrative HCC is difficult to distinguish against the background cirrhotic liver.
View Article and Find Full Text PDFProtocol for the economic evaluation of integrated community-based care compared with integrated facility-based care for HIV, hypertension and diabetes in Tanzania and Uganda (INTE-COMM trial).
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University College London, Institute for Global Health, London, England, WC1N 1EH, UK.
Background: The number of people living with multiple chronic conditions in sub-Saharan Africa is increasing, but health facilities are unable to meet demand. To improve health system capacity and access to care, community models of HIV care have been trialled in countries such as Tanzania and Uganda. However, no evidence exists to inform policymakers on the effectiveness and cost-effectiveness of integrated community-based models of care for HIV and chronic non-communicable conditions.
View Article and Find Full Text PDFCatastrophic expenditure associated with childhood hospitalisation for acute illness in Kenya and Uganda: a cross-sectional study.
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Unlabelled: Policy Points The World Health Organization (WHO) Model Lists of Essential Medicines (EML) aims to select clinically beneficial and cost-effective medicines that ought to be prioritized by health systems based on the priority needs of their populations. However, the rapid evolution within the pharmaceutical sector toward complex, high-priced medicines has challenged WHO decision making in recent years, as evidenced by earlier literature demonstrating inconsistencies in the application of decision criteria and recommendations. Proposed solutions to these challenges focus on technical aspects of the program, such as refining the quality of evidence in applications, improving the connection with guidelines, and using evidence assessment frameworks.
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