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A glomerulus chip with spherically twisted cell-laden hollow fibers as glomerular capillary tufts.
Biofabrication
April 2023
Department of Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, People's Republic of China.
Glomerulus-on-a-chip, as a promising alternative for drug nephrotoxicity evaluation, is attracting increasing attention. For glomerulus-on-a-chip, the more biomimetic the chip is, the more convincing the application of the chip is. In this study, we proposed a hollow fiber-based biomimetic glomerulus chip that can regulate filtration in response to blood pressure and hormone levels.
View Article and Find Full Text PDFThe podocyte as a direct target of glucocorticoids in nephrotic syndrome.
Nephrol Dial Transplant
September 2022
Department of Pathology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Nephrotic syndrome (NS) is characterized by massive proteinuria; podocyte loss or altered function is a central event in its pathophysiology. Treatment with glucocorticoids is the mainstay of therapy, however, many patients experience one or multiple relapses and prolonged use may be associated with severe adverse effects. Recently the beneficial effects of glucocorticoids have been attributed to a direct effect on podocytes in addition to the well-known immunosuppressive effects.
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1 Department of Surgery, Oulu University Hospital, Oulu, Finland. 2 Division of Transplantation Surgery, Department of Surgery, The Ohio State University Wexner Medical Center, Comprehensive Transplant Center, Columbus, OH. 3 Department of Mechanical and Industrial Engineering, Qatar University, Doha, Qatar.
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