AI Article Synopsis
- The study collected blood samples from relapsing fever patients in Jask County, Iran, and identified their borrelial strains through genetic sequencing.
- The sequences showed a close relation to certain East African borreliae species and highlighted a unique genetic marker distinguishing them from other strains.
- The findings suggest that the local tick, O. erraticus, may play a role in the transmission and ecology of these borrelial species, indicating an endemic presence in specific regions of southern Iran.
Article Abstract
We obtained two blood samples from relapsing fever patients residing in Jask County, Hormozgan Province, southern Iran in 2013. Sequencing of a partial fragment of glpQ from two samples, and further characterization of one of them by analyzing flaB gene, and 16S-23S spacer (IGS) revealed the greatest sequence identity with East African borreliae, Borrelia recurrentis, and Borrelia duttonii, and Borrelia microti from Iran. Phylogenetic analyses of glpQ, flaB, and concatenated sequences (glpQ, flab, and IGS) clustered these sequences amongst East African Relapsing fever borreliae and B. microti from Iran. However, the more discriminatory IGS disclosed a unique 8-bp signature (CAGCCTAA) separating these from B. microti and indeed other relapsing fever borreliae. In southern Iran, relapsing fever cases are mostly from localities in which O. erraticus ticks, the notorious vector of B. microti, prevail. There are chances that this argasid tick serves as a host and vector of several closely related species or ecotypes including the one we identified in the present study. The distribution of this Borrelia species remains to be elucidated, but it is assumed to be endemic to lowland areas of the Hormozgan Province, as well as Sistan va Baluchistan in the southeast and South Khorasan (in Persian: Khorasan-e Jonobi) in the east of Iran.
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| http://dx.doi.org/10.1016/j.ttbdis.2017.07.006 | DOI Listing |
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