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Preface: Global Health Security in Vision Care: Addressing Disparities, Outbreaks, and Conflict.
Int Ophthalmol Clin
October 2024
Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear, University of Illinois Chicago, Chicago, IL.
Preface.
J Assoc Physicians India
September 2024
Global Chief Medical Officer, Cipla Ltd., Mumbai, India, Corresponding Author.
The field of diuretic therapy has witnessed significant advancements over the decades. Loop diuretics and other diuretic agents are crucial in the management of various conditions characterized by fluid overload. Torsemide, a loop diuretic agent, has unique pharmacological properties, safety profiles, and varied clinical applications.
View Article and Find Full Text PDFBioactive Phyto-Compounds with Antimicrobial Effects and AI: Results of a Desk Research Study.
Microorganisms
May 2024
Department of Social Medicine and Health Care Organisation, Faculty of Public Health, Medical University of Varna, 9002 Varna, Bulgaria.
Resistance of microorganisms to antibiotics represents a formidable global challenge, manifesting in intricate public health ramifications including escalated mortality rates and augmented healthcare costs. The current efforts to manage antimicrobial resistance (AMR) are limited mainly to the standard therapeutic approaches. The aim of this study is to present and analyze the role of artificial intelligence (AI) in the search for new phyto-compounds and novel interactions with antimicrobial effects.
View Article and Find Full Text PDFPreface to the special issue of Food and Chemical Toxicology on "New approach methodologies and machine learning in food safety and chemical risk assessment: Development of reproducible, open-source, and user-friendly tools for exposure, toxicokinetic, and toxicity assessments in the 21st century".
Food Chem Toxicol
August 2024
Department of Environmental Sciences, College of Natural and Agricultural Sciences, University of California, Riverside, CA 92521, United States.
This Special Issue contains articles on applications of various new approach methodologies (NAMs) in the field of toxicology and risk assessment. These NAMs include in vitro high-throughput screening, quantitative structure-activity relationship (QSAR) modeling, physiologically based pharmacokinetic (PBPK) modeling, network toxicology analysis, molecular docking simulation, omics, machine learning, deep learning, and "template-and-anchor" multiscale computational modeling. These in vitro and in silico approaches complement each other and can be integrated together to support different applications of toxicology, including food safety assessment, dietary exposure assessment, chemical toxicity potency screening and ranking, chemical toxicity prediction, chemical toxicokinetic simulation, and to investigate the potential mechanisms of toxicities, as introduced further in selected articles in this Special Issue.
View Article and Find Full Text PDFWhy Language Matters in Digital Endpoint Development: Harmonized Terminology as a Key Prerequisite for Evidence Generation.
Digit Biomark
January 2024
Johnson and Johnson Innovative Medicine, Allschwil, Switzerland.
Background: Developments in the field of digital measures and digitally derived endpoints demand greater attention on globally aligned approaches to enhance digital measure acceptance by regulatory authorities and health technology assessment (HTA) bodies for decision-making. In order to maximize the value of digital measures in global drug development programs and to ensure study teams and regulators are referring to the same items, greater alignment of concepts, definitions, and terminology is required. This is a fast-moving complex field; every day brings new technologies, algorithms, and possibilities.
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