AI Article Synopsis
- Recent studies show that serum levels of SCCA1 and SCCA2, which are influenced by type 2 cytokines, are higher in patients with atopic dermatitis (AD), but the specific role of SCCA2 in AD patients has not been thoroughly investigated.
- This study analyzed serum SCCA2 levels in 240 adult AD patients and 25 healthy controls, correlating these levels with clinical characteristics and other laboratory indicators.
- Results indicated that serum SCCA2 levels are positively correlated with AD severity, and levels decreased after treatment, suggesting that SCCA2 could be a useful biomarker for assessing and managing AD.*
Article Abstract
Background: Recent studies have indicated that serum levels of squamous cell carcinoma antigen (SCCA) 1 and 2 induced by type 2 cytokines such as IL-4 and IL-13, are increased in patients with atopic dermatitis (AD). However, no clinical studies have analyzed serum levels of SCCA2 in larger series of AD patients or their association with various clinical characteristics. This study was performed to clarify whether serum levels of SCCA2 are associated with disease severity and clinical phenotypes of adult AD patients.
Methods: An enzyme-linked immunosorbent assay was performed to examine serum SCCA2 levels in 240 adult patients with AD and 25 healthy controls in this study. Serum SCCA2 levels were analyzed with clinical characteristics and laboratory parameters including thymus and activation-regulated chemokine (TARC), lactate dehydrogenase (LDH), blood eosinophils, total IgE, and specific IgE (Japanese cedar pollen, Dermatophagoides farina, Candida, malassezia, Staphylococcal enterotoxin B). Expression of SCCA2 in AD eruption was examined by immunohistochemistry. The effect of treatment on serum SCCA2 was also assessed.
Results: Serum SCCA2 level showed a positive correlation with disease severity, levels of TARC, LDH, eosinophil counts, and IgE levels. Robust expression of SCCA2 was detected in the supra basal keratinocytes in the epidermis of AD patients. Serial measurements of serum SCCA2 revealed decreased levels of SCCA2 after treatment for AD.
Conclusions: Serum SCCA2 levels reflected disease severity and clinical type of AD. Serum SCCA2 may thus be a relevant biomarker for AD.
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| http://dx.doi.org/10.1016/j.alit.2017.06.016 | DOI Listing |
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